Emam, S., Abdelrahman, S., Hasan, A., EL- Melouk, M. (2023). Hypervirulent Klebsiella pneumoniae at Benha University Hospitals. The Egyptian Journal of Hospital Medicine, 90(2), 3592-3597. doi: 10.21608/ejhm.2023.292752
Sherin M. Emam; Sawsan Abdelrahman; Amany Abdelaziz Hasan; Marwa S. EL- Melouk. "Hypervirulent Klebsiella pneumoniae at Benha University Hospitals". The Egyptian Journal of Hospital Medicine, 90, 2, 2023, 3592-3597. doi: 10.21608/ejhm.2023.292752
Emam, S., Abdelrahman, S., Hasan, A., EL- Melouk, M. (2023). 'Hypervirulent Klebsiella pneumoniae at Benha University Hospitals', The Egyptian Journal of Hospital Medicine, 90(2), pp. 3592-3597. doi: 10.21608/ejhm.2023.292752
Emam, S., Abdelrahman, S., Hasan, A., EL- Melouk, M. Hypervirulent Klebsiella pneumoniae at Benha University Hospitals. The Egyptian Journal of Hospital Medicine, 2023; 90(2): 3592-3597. doi: 10.21608/ejhm.2023.292752
Hypervirulent Klebsiella pneumoniae at Benha University Hospitals
Background: Hypervirulent Klebsiella pneumoniae (hvKP) is a virulent subtype of K. Pneumoniae. It commonly causes a serious community acquired infections, but it can also cause hospital acquired (nosocomial) infections. Emergence of antimicrobial resistance in hvKP ia a cause of concern. Objective: Phenotypic and molecular characterization and differentiation of classical and hypervirulent klebsiella pneumoniae isolated from Benha University Hospital. Subjects and methods: Klebsiella pneumoniae was isolated bycultivation on Mac-Conkey agar media. Identified phenotypically and subjected to antibiotic sensitivity test. Conventional PCR was performed for detection of RmpA and RmpA2 virulence genes. Results: Eight strains out of 70 (11.4%) K.Pneumoniae were identified as probable hvKP by detection of RmpA2 that was detected in all hvKP while rmpA was detected in 2 out of 8 hvKP isolates. Both cKP and hvKP isolates exhibited high resistance rates for most of the tested antibiotics. Conclusion: Particularly in the presence of antibiotic resistance, HvKP pose a new hazard. Both Rmp A and Rmp A2 virulence genes were strongly associated with hvKP.