Shaat, R., Abd El Ghaffar, H., Shamaa, S., Abdel-Masseih, H., Elbaz, O. (2023). Clinicopathological Significance of A20 Genetic Mutation in Diffuse Large B-Cell Lymphoma. The Egyptian Journal of Hospital Medicine, 90(1), 1680-1683. doi: 10.21608/ejhm.2023.283683
Rana M. Shaat; Hasan A. Abd El Ghaffar; Sameh Shamaa; Hanaa M. Abdel-Masseih; Osama Elbaz. "Clinicopathological Significance of A20 Genetic Mutation in Diffuse Large B-Cell Lymphoma". The Egyptian Journal of Hospital Medicine, 90, 1, 2023, 1680-1683. doi: 10.21608/ejhm.2023.283683
Shaat, R., Abd El Ghaffar, H., Shamaa, S., Abdel-Masseih, H., Elbaz, O. (2023). 'Clinicopathological Significance of A20 Genetic Mutation in Diffuse Large B-Cell Lymphoma', The Egyptian Journal of Hospital Medicine, 90(1), pp. 1680-1683. doi: 10.21608/ejhm.2023.283683
Shaat, R., Abd El Ghaffar, H., Shamaa, S., Abdel-Masseih, H., Elbaz, O. Clinicopathological Significance of A20 Genetic Mutation in Diffuse Large B-Cell Lymphoma. The Egyptian Journal of Hospital Medicine, 2023; 90(1): 1680-1683. doi: 10.21608/ejhm.2023.283683
Clinicopathological Significance of A20 Genetic Mutation in Diffuse Large B-Cell Lymphoma
Background: Activation of pathway of nuclear factor kappaB (NF-κB) which is caused by genetic alterations has been reported in B cell lymphoma. A20 gene is considered main regulator component of NF-κB signaling. Its function is mainly suppression of this pathway. Deletions and/or mutations in A20 gene cause inactivation of this pathway which were found in various hematologic malignancies. Objective: The current study aims to determine the prevalence of A20 gene mutations and their relationship with the clinical and laboratory profile in diffuse large B-cell lymphoma (DLBCL). Patients and methods: A total 100 DLBCL patients were investigated for A20 gene mutation by real time polymerase chain reaction. Results: A20 gene mutation GA mutant genotype was found in 18% of the patients, where 77.8% of them were ABC-DLBCL subtypes. GA heterozygous genotype was frequently associated with stage IV and extra-nodal infiltration, and shorter overall survival (OS). Conclusion: Our study suggests a role of A20 gene mutation in DLBCL pathogenesis as well as its prognosis.