Atteq, R., Siam, A., AbdElmonem, D., Risha, A. (2023). Diagnostic Value of Interleukin 1 Receptor Antagonist (IL-1RA) in Children with Refractory Epilepsy. The Egyptian Journal of Hospital Medicine, 90(1), 1611-1616. doi: 10.21608/ejhm.2023.283671
Rhoyda Essam Moustafa Atteq; Ahmed Galal Siam; Doaa Metwaly AbdElmonem; Amr I. Risha. "Diagnostic Value of Interleukin 1 Receptor Antagonist (IL-1RA) in Children with Refractory Epilepsy". The Egyptian Journal of Hospital Medicine, 90, 1, 2023, 1611-1616. doi: 10.21608/ejhm.2023.283671
Atteq, R., Siam, A., AbdElmonem, D., Risha, A. (2023). 'Diagnostic Value of Interleukin 1 Receptor Antagonist (IL-1RA) in Children with Refractory Epilepsy', The Egyptian Journal of Hospital Medicine, 90(1), pp. 1611-1616. doi: 10.21608/ejhm.2023.283671
Atteq, R., Siam, A., AbdElmonem, D., Risha, A. Diagnostic Value of Interleukin 1 Receptor Antagonist (IL-1RA) in Children with Refractory Epilepsy. The Egyptian Journal of Hospital Medicine, 2023; 90(1): 1611-1616. doi: 10.21608/ejhm.2023.283671
Diagnostic Value of Interleukin 1 Receptor Antagonist (IL-1RA) in Children with Refractory Epilepsy
Background: Clinical studies have shown that prolonged seizures result in increased cytokine production in the central nervous system. Aim of work: To focus on diagnostic value of interleukin-1 receptor antagonists in refractory epilepsy. Patients and methods: This case-control investigation was done in Pediatric Neurology Unit and Pediatric Neurology Clinics, Faculty of Medicine, Zagazig University. Children were classified into: patient group: 59 children with refractory epilepsy aged between 1 year and 16 years old and control group: 59 healthy children who are age and sex corresponded to the patient population. Serum level of IL-1Ra was assessed. Results: There is significant higher value of plasma of interleukin1 receptor antagonist in studied refractory epilepsy group compared to the healthy control group. Conclusion: Interleukin-1 receptor antagonist can differentiate the control group and the seizure group.