Hamed, D., El Kholy, B., El Deen, H., Momen, S., Selim, N. (2023). The XRay Repair Cross Complementing 1(XRCC1) Rs25487 Variation and Susceptibility to Cirrhosis in Patients with Chronic Hepatitis C Virus. The Egyptian Journal of Hospital Medicine, 90(1), 453-458. doi: 10.21608/ejhm.2023.279660
Dalia Hamed; Badawy El Kholy; Hadeel Gamal El Deen; Samar Mahmoud Mohammed Momen; Nora Mahmoud Selim. "The XRay Repair Cross Complementing 1(XRCC1) Rs25487 Variation and Susceptibility to Cirrhosis in Patients with Chronic Hepatitis C Virus". The Egyptian Journal of Hospital Medicine, 90, 1, 2023, 453-458. doi: 10.21608/ejhm.2023.279660
Hamed, D., El Kholy, B., El Deen, H., Momen, S., Selim, N. (2023). 'The XRay Repair Cross Complementing 1(XRCC1) Rs25487 Variation and Susceptibility to Cirrhosis in Patients with Chronic Hepatitis C Virus', The Egyptian Journal of Hospital Medicine, 90(1), pp. 453-458. doi: 10.21608/ejhm.2023.279660
Hamed, D., El Kholy, B., El Deen, H., Momen, S., Selim, N. The XRay Repair Cross Complementing 1(XRCC1) Rs25487 Variation and Susceptibility to Cirrhosis in Patients with Chronic Hepatitis C Virus. The Egyptian Journal of Hospital Medicine, 2023; 90(1): 453-458. doi: 10.21608/ejhm.2023.279660
The XRay Repair Cross Complementing 1(XRCC1) Rs25487 Variation and Susceptibility to Cirrhosis in Patients with Chronic Hepatitis C Virus
Background: Around 130–170 million individuals are thought to be affected with the hepatitis C virus (HCV), which is a viral pandemic and the leading cause of persistent liver illness. The frequency of HCV infections is greatest in Egypt, where more than 10% of the general population is affected. Objective: The purpose of the current study was to confirm any potential associations between cirrhosis and the XRCC1 rs25487 variant in chronic HCV patients. Patients and methods: A fibroscan was conducted on 80 HCV +ve patients and 40 control participants for a total of 120 people to determine the extent of hepatic fibrosis. Real-time PCR was used to examine the SNP genotyping in the XRCC1 gene (rs25487). Results: There were no substantial variation in the prevalence of different genotypes in XRCC1 A > G (GG and AG) between non cirrhotic and cirrhotic in chronic HCV Egyptian patients. Conclusion: By comparing the incidence of the various genotypes (AA, AG, and GG) in the analyzed groups, no clear pattern of relationship could be seen (p=0.225). (P = 0.410) There was no distinguishable pattern of connection between the AA genotype and the other genotypes (GG and AG). Comparing the frequencies of the two alleles (A and G alleles) in the three groups under study revealed no evidence of a connection.