Hassan, B., Ahmed, H., El-Gebaly, S., Mahjoub, A. (2022). Serum Connective Tissue Growth Factor in Children with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease: Review Article. The Egyptian Journal of Hospital Medicine, 89(2), 6419-6421. doi: 10.21608/ejhm.2022.269984
Beshier Abdallah Hassan; Hanan Samir Ahmed; Sherief Mohammed El-Gebaly; Ahmed Fawzy Fahmy Mahjoub. "Serum Connective Tissue Growth Factor in Children with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease: Review Article". The Egyptian Journal of Hospital Medicine, 89, 2, 2022, 6419-6421. doi: 10.21608/ejhm.2022.269984
Hassan, B., Ahmed, H., El-Gebaly, S., Mahjoub, A. (2022). 'Serum Connective Tissue Growth Factor in Children with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease: Review Article', The Egyptian Journal of Hospital Medicine, 89(2), pp. 6419-6421. doi: 10.21608/ejhm.2022.269984
Hassan, B., Ahmed, H., El-Gebaly, S., Mahjoub, A. Serum Connective Tissue Growth Factor in Children with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease: Review Article. The Egyptian Journal of Hospital Medicine, 2022; 89(2): 6419-6421. doi: 10.21608/ejhm.2022.269984
Serum Connective Tissue Growth Factor in Children with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease: Review Article
Background: The significant pulmonary vascular resistance can result in right-sided heart failure, elevated pulmonary vascular resistance, and even mortality, a progressive condition known as pulmonary arterial hypertension (PAH), which also has a high mortality and morbidity rate. Objectives: we aimed investigate plasma connective tissue growth factor (CTGF) levels in pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD) (PAH-CHD) in children and the relationships of CTGF with hemodynamic parameters. Material and methods: A review of MEDLINE, Cochrane Library, ClinicalTrials.gov, indexed through 31 October 2022, utilizing the following searches: connective tissue growth factor OR/AND one of the following: Biomarker; Children; Congenital heart disease; Pulmonary arterial hypertension [MESH], was conducted. Additional studies were identified through review of references. English-language epidemiological studies, clinical studies, and case reports/series of connective tissue growth factor was included. The authors reached consensus regarding study inclusion after full-text review. The body of literature was assessed for bias qualitatively. Conclusion: Children with PAH-CHD had considerably higher serumconnective tissue growth factor (CTGF) levels, which were inversely linked with oxygen saturation. The parameters of the echocardiograph and CTGF did not correlate. A possible diagnostic biomarker for PAH-CHD in children may be found in serum CTGF levels.