Mohammad, M., Sallam, A., Fekry, A., Amin, M. (2021). Study of Omentin-1 and Chemerin as Predictors of Coronary Artery Disease in Elderly Patients, with Retrospective Studying of their Relation to Diabetes Mellitus Type 2. The Egyptian Journal of Hospital Medicine, 83(1), 995-1001. doi: 10.21608/ejhm.2021.160044
Maher Borai Mohammad; Ahmad Soliman Sallam; Abeer Abdalla Fekry; Mohammad Ibrahim Amin. "Study of Omentin-1 and Chemerin as Predictors of Coronary Artery Disease in Elderly Patients, with Retrospective Studying of their Relation to Diabetes Mellitus Type 2". The Egyptian Journal of Hospital Medicine, 83, 1, 2021, 995-1001. doi: 10.21608/ejhm.2021.160044
Mohammad, M., Sallam, A., Fekry, A., Amin, M. (2021). 'Study of Omentin-1 and Chemerin as Predictors of Coronary Artery Disease in Elderly Patients, with Retrospective Studying of their Relation to Diabetes Mellitus Type 2', The Egyptian Journal of Hospital Medicine, 83(1), pp. 995-1001. doi: 10.21608/ejhm.2021.160044
Mohammad, M., Sallam, A., Fekry, A., Amin, M. Study of Omentin-1 and Chemerin as Predictors of Coronary Artery Disease in Elderly Patients, with Retrospective Studying of their Relation to Diabetes Mellitus Type 2. The Egyptian Journal of Hospital Medicine, 2021; 83(1): 995-1001. doi: 10.21608/ejhm.2021.160044
Study of Omentin-1 and Chemerin as Predictors of Coronary Artery Disease in Elderly Patients, with Retrospective Studying of their Relation to Diabetes Mellitus Type 2
1Departments of 1Clinical Pathology Faculty of Medicine, Zagazig University, Egypt
2Departments of Cardiology, Faculty of Medicine, Zagazig University, Egypt.
Abstract
Monocyte chemoattractant protein-1 (MCP-1) is the first discovered and most extensively studied chemotactic cytokines (CC = chemokine). Many studies on its role in the etiologies of obesity- and diabetes-related diseases have been increased exponentially during the past two decades. MCP-1, a chemokine involved in monocyte chemotaxis can be consistently found at high levels in the patients with type 2 diabetes mellitus. MCP1 may be an early predictor of complications of diabetes. Objective: Assessment of the levels of MCP-1 and other biochemical markers in diabetic subjects compared to a healthy group, which in turn can be beneficial to clarify the correlations of MCP-1 levels in diabetes mellitus with other clinical and biochemical parameters. Patients and methods: Eighty-one participants including both male and female, of cross-matched ages ranging between 30 – 60 years old were included in this study. They were divided into three equal groups: group I (control group), group II (recently diagnosed T2DM) and group III (old diagnosed T2DM more than 10 years). Results: The highest level of MCP-1 was found in the old diagnosed diabetic group while the lowest level was found in the non-diabetic control group. The LSD statistical analysis showed there was significant difference between all groups of the study. Our results showed that serum MCP-1 was elevated in cases of the group 3 (old diagnosed diabetic patients) who were suffering from diabetic nephropathy (9/27), diabetic retinopathy (9/27) and the last 9/27 were suffering of neuropathy. Conclusion: The MCP-1 level is increased in type 2 Diabetic patients and significantly increased with the progression of diabetes complications as diabetic retinopathy, diabetic nephropathy and diabetic neuropathy.