Randomized controlled trial comparing pregnancy outcome using artificial versus letrozole stimulated cycle in cryo preserved embryo transfer

Document Type : Original Article

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Department of Obstetrics and Gynecology, Faculty of Medicine, Al Azhar University

Abstract

Background: Intracytoplasmic sperm injection (ICSI) is a procedure performed in the IVF embryo laboratory after the eggs have been retrieved from the ovaries and involves placing a single sperm directly inside the egg. It is indicated for cases which involve very low sperm counts or motility. Aim of the Work: To compare the outcome of pregnancy using artificial and letrozol stimulated cycle in cryo preserved embryo transfer. Patients and Methods: This randomized controlled trial was conducted on 190 patients attending the clinic submitted for embryo transfer of cryo embryos. All cycles were performed at international Islamic Center for population Studies and Research Assisted Reproduction Unit (ART unit IICPSR) at Al-Azhar University and evidence based centers. Results: Pregnancy rate was significantly higher in letrozole (53.2%) compared to the artificial group (40.6%). Furthermore, first trimester abortion rate was non-significantly lower in letrozole group. Conclusion: ovulation induction with letrozole during endometrial preparation for cryopreserved ET has a significantly higher ongoing pregnancy rate than artificial cycle. The reported ongoing pregnancy rate in letrozole arm was encouraging and may provide an alternative mean to artificial cycles in endometrial preparation in FET.

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The Egyptian Journal of Hospital Medicine
Volume 72, Issue 6
July 2018
Pages 4644-4649

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