Abdel Aty, S., El Sharawy, B., Abdel Maksoud, S., Raafat, E., Ghareeb, M. (2018). Plasma Factor VII and Histidine-Rich Glycoprotein as A Potential Markers in Pre Eclampsia. The Egyptian Journal of Hospital Medicine, 72(5), 4533-4538. doi: 10.21608/ejhm.2018.9539
Sanaa Mohamed Abdel Aty; Buthyna Ahmed El Sharawy; Sahar Abdel Maksoud; Entsar Raafat; Mahmoud Ahmed Ghareeb. "Plasma Factor VII and Histidine-Rich Glycoprotein as A Potential Markers in Pre Eclampsia". The Egyptian Journal of Hospital Medicine, 72, 5, 2018, 4533-4538. doi: 10.21608/ejhm.2018.9539
Abdel Aty, S., El Sharawy, B., Abdel Maksoud, S., Raafat, E., Ghareeb, M. (2018). 'Plasma Factor VII and Histidine-Rich Glycoprotein as A Potential Markers in Pre Eclampsia', The Egyptian Journal of Hospital Medicine, 72(5), pp. 4533-4538. doi: 10.21608/ejhm.2018.9539
Abdel Aty, S., El Sharawy, B., Abdel Maksoud, S., Raafat, E., Ghareeb, M. Plasma Factor VII and Histidine-Rich Glycoprotein as A Potential Markers in Pre Eclampsia. The Egyptian Journal of Hospital Medicine, 2018; 72(5): 4533-4538. doi: 10.21608/ejhm.2018.9539
Plasma Factor VII and Histidine-Rich Glycoprotein as A Potential Markers in Pre Eclampsia
Clinical Pathology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt And Obstetrics And Gynecology Department, Zagazig Faculty Of Medicine, Zagazig, Egypt
Abstract
Background: Preeclampsia (PE) is a complex and serious multi-system disorder of pregnancy with a worldwide incidence of 5-7% and contributes significantly to maternal and perinatal morbidity and mortality. Normal pregnancy is associated with a local hypercoagulable state that becomes more profound in PE. Histidine-rich glycoprotein (HRG) is a protein interacting with angiogenesis, coagulation, and inflammatory responses, processes known to be altered in preeclamptic pregnancies. Aim of the work: Is to analyze changes in the circulating levels of plasma factor VII (Plasma F VII) and HRG in women developing PE and to evaluate them as markers for early diagnosis of PE. Subjects and Methods: This study was carried out on 80 pregnant women after 20 weeks of gestation. The subjects were divided into: Group I (G1): 40 cases with preeclampsia; Group II (G2): 40 normal pregnant women who were matched for age and gestational period. Plasma FVII and HRG were measured by ELISA Results: Plasma FVII levels were significantly higher in G1 (206.22 ± 46.25 ng/ml) as compared to G2 (97.46 ± 21.95 ng/ml) (p<0.001). Significant positive correlation of plasma FVII with fibrinogen and significant negative correlation with platelet count and HRG were detected. At cut off 125.75 ng/ml plasma FVII levels shows high sensitivity and specificity (95%). HRG levels were significantly lower in G1 (37.1 ± 7.52 pg/ml) as compared with G2 (79.87±24.15 pg/ml) (p<0.001). HRG shows significant positive correlation with platelet count and significant negative correlation with each of fibrinogen and plasma FVII. At cut off 46.45 pg/ml. HRG shows high sensitivity (92.5%) and specificity (87.5%). Conclusion: Plasma FVII and HRG can be used as early marker for detection of PE.
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