Abd-El Kader, S., Ahmad, Y., El-Ghamry, E., Tawfik, S., Atia, W., Keder, M. (2018). Assessment of Vitamin D Status In Patients With Essential Hypertension. The Egyptian Journal of Hospital Medicine, 72(5), 4434-4438. doi: 10.21608/ejhm.2018.9496
Sameh Ahmad Abd-El Kader; Youssef Khalel Ahmad; Esam Mohamed El-Ghamry; Salwa Tawfik; Wael Mohamed Atia; Mohammad Mohammad Keder. "Assessment of Vitamin D Status In Patients With Essential Hypertension". The Egyptian Journal of Hospital Medicine, 72, 5, 2018, 4434-4438. doi: 10.21608/ejhm.2018.9496
Abd-El Kader, S., Ahmad, Y., El-Ghamry, E., Tawfik, S., Atia, W., Keder, M. (2018). 'Assessment of Vitamin D Status In Patients With Essential Hypertension', The Egyptian Journal of Hospital Medicine, 72(5), pp. 4434-4438. doi: 10.21608/ejhm.2018.9496
Abd-El Kader, S., Ahmad, Y., El-Ghamry, E., Tawfik, S., Atia, W., Keder, M. Assessment of Vitamin D Status In Patients With Essential Hypertension. The Egyptian Journal of Hospital Medicine, 2018; 72(5): 4434-4438. doi: 10.21608/ejhm.2018.9496
Assessment of Vitamin D Status In Patients With Essential Hypertension
4Clinical Pathology Department, Faculty of Medicine, Al-Azhar University
Abstract
Background: There is close relationship between Vit D deficiency and hypertension. It was found that Vit D is potent inhibitor of Renin Aldosterone Angiotensin System (RAAS) which is the main mechanism responsible for development of hypertension. Aim of The Work: To assess the role of vitamin D deficiency in the development of essential hypertension and aggravation of its vascular complications. Subjects and Methods: This study was conducted on 80 individuals. Individuals were divided into two groups: Group 1: comprising 60 patients with essential hypertension. Group 2: comprising 20 healthy individuals. All individuals included in the study were submitted to: Complete history and physical examinations to evaluate exclusion criteria. Liver and renal function tests, fasting and PP blood glucose, CBC, lipid profile, serum vitamin D (25hydroxycholecalciferol), serum Ca & Ph. Doppler study on carotid artery to assess vascular complications and Echocardiography to assess ventricular mass was done. Results: There was statistically significant decrease (p value <0.05) in vitamin D in patients group in comparison to control group. There was highly statistically significant increase (p value <0.001) in intimal thickness and left ventricular mass in patients with low vitamin D level in comparison to patients with normal vitamin D level. In the patient group, 6 patients (10%) were suffering from vitamin D deficiency while 30 (50%) were suffered from vitamin D insufficiency while 24 (35%) show normal levels of vitamin D. Interestingly, intimal thickness and ventricular mass were significantly higher in patients with essential hypertension with low vitamin D than those with normal vitamin D levels. Conclusions: Vitamin D deficiency occurs in the majority of essential hypertension patients and therefore decreased serum vitamin D levels is considered an additional risk factor for cardiovascular morbidity and mortality.
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