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Marwa Ali1 and Ghada Mohamed1, F. (2018). Evaluation of The Diagnostic Role of Non-Coding RNA and Exosomal Related Gene Association in Lung Cancer. The Egyptian Journal of Hospital Medicine, 72(3), 4148-4153. doi: 10.21608/ejhm.2018.9131
Fawzia Khalil1, Hanan H. Shehata1, Nehad Osman2, Omar Abdel-Rahman3, Marwa Ali1 and Ghada Mohamed1. "Evaluation of The Diagnostic Role of Non-Coding RNA and Exosomal Related Gene Association in Lung Cancer". The Egyptian Journal of Hospital Medicine, 72, 3, 2018, 4148-4153. doi: 10.21608/ejhm.2018.9131
Marwa Ali1 and Ghada Mohamed1, F. (2018). 'Evaluation of The Diagnostic Role of Non-Coding RNA and Exosomal Related Gene Association in Lung Cancer', The Egyptian Journal of Hospital Medicine, 72(3), pp. 4148-4153. doi: 10.21608/ejhm.2018.9131
Marwa Ali1 and Ghada Mohamed1, F. Evaluation of The Diagnostic Role of Non-Coding RNA and Exosomal Related Gene Association in Lung Cancer. The Egyptian Journal of Hospital Medicine, 2018; 72(3): 4148-4153. doi: 10.21608/ejhm.2018.9131

Evaluation of The Diagnostic Role of Non-Coding RNA and Exosomal Related Gene Association in Lung Cancer

Article 19, Volume 72, Issue 3, July 2018, Page 4148-4153  XML PDF (351.76 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2018.9131
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Author
Fawzia Khalil1, Hanan H. Shehata1, Nehad Osman2, Omar Abdel-Rahman3, Marwa Ali1 and Ghada Mohamed1
1 Medical Biochemistry and Molecular Biology Department, 2 Pulmonary Medicine Department, Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine –Ain Shams University
Abstract
Background: Exosomes are microvesicles that are recently discovered in intercellular communication especially between tumor cells as lung cancer that are important for tumor development and progression. Objectives: Examine the diagnostic role of serum exosomal LncRNA in lung cancer among Egyptian population.
Methods: Lung cancer characteristic exosomal RNA-based biomarker Lnc-RNA-RP11-510M2.10 was selected based on bioinformatic methods, followed by RT-qPCR validation of their expression in serum of 20 patients with lung cancer and 10 healthy volunteers.
Results: serum exosomal Lnc-RNA-RP11-510M2.10 showed a significant negative association with lung cancer patients in comparison to patients with healthy persons (p<0.001).
Conclusion: Lnc-RNA-RP11-510M2.10 could be used as diagnostic and prognostic biomarker tools for lung cancer.
Keywords
Lung Cancer; Exosomal RNA extraction; Lnc-RNA-RP11-510M2.10
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