Evaluation of Serum Asprosin Level in Development of Diabetic Nephropathy in Elderly Type 2 Diabetic Patients

Gouda, Asmaa Musatafa; Mohamed, Azza Hassan; Saad, Marwa Ahmed; Mohsen, Ahmed Mohamed; Saad, Sawsan Samir

doi:10.21608/ejhm.2025.418460.1830

Evaluation of Serum Asprosin Level in Development of Diabetic Nephropathy in Elderly Type 2 Diabetic Patients

Document Type : Original Article

Authors

¹ Lecturer at Clinical and chemical pathology department, Faculty of medicine, Alexandria University, Alexandria, Egypt

² Internal Medicine Department (Geriatric unit), Faculty of Medicine, Alexandria University, Egypt

10.21608/ejhm.2025.418460.1830

Abstract

Background: Diabetic nephropathy (DN), a serious kidney consequence brought on by persistent hyperglycemia, hypertension, and metabolic stress, is largely caused by type 2 diabetes mellitus (T2DM). Diabetes causes a rise in asprosin, an adipose-derived hormone that raises blood sugar and has been linked to insulin resistance and inflammation. Although DN has been linked to higher asprosin, its clinical implications are still unknown.
Aim of the work: The objectives of this study are to assess blood asprosin levels in older patients with type 2 diabetes and to investigate its potential as a predictive marker for diabetic nephropathy.
Patients and Methods: T2DM patients with diabetic nephropathy (Group 2), non-diabetic controls (Group 1), and T2DM patients without diabetic nephropathy (Group 3) were the three equal groups of 105 people aged ≥65 years who participated in this cross-sectional study. The Alexandria Main University Hospital's Internal Medicine and Geriatrics clinics served as the source of participants. Levels of serum asprosin were assessed and contrasted between groups.
Results: Group 2 showed significantly higher serum asprosin levels compared to Groups 1 and 3 (90.09 ± 1.15 vs. 28.92 ± 10.12 vs. 18.58 ± 5.96 ng/mL; p<.001). A cutoff value of >41.85 ng/mL effectively differentiated DN cases, with 94.29% sensitivity, 91.43% specificity, and an AUC of 0.9.
Conclusion: Elevated serum asprosin is strongly associated with diabetic nephropathy in elderly T2DM patients. According to these results, asprosin may serve as a helpful biomarker for early detection and a possible target for treatment in the management of diabetic kidney problems.

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