Evaluation of Ascitic Calprotectin Level in Diagnosis of Spontaneous Bacterial Peritonitis in HCV Egyptian Patients with Liver Cirrhosis and Its Outcome

Bahnacy, Abd-allah; Hussieny, Basma; Gadallah, Abdel-Naser Abdel-Atty

doi:10.21608/ejhm.2025.411867.1815

Evaluation of Ascitic Calprotectin Level in Diagnosis of Spontaneous Bacterial Peritonitis in HCV Egyptian Patients with Liver Cirrhosis and Its Outcome

Document Type : Original Article

Authors

¹ Gastroenterology and Hepatology department, Faculty of Medicine, Menoufia University

² 1Gastroenterology and Hepatology department, Faculty of Medicine, Menoufia University.

³ Internal Medicine, Gastroenterology, Hepatology & Endoscopy department, Faculty of Medicine - Menoufia University, Shebin Elkom, Menoufia, Egypt

10.21608/ejhm.2025.411867.1815

Abstract

Background: A dangerous side effect of cirrhosis, particularly in people with hepatitis C, is spontaneous bacterial peritonitis (SBP). A diagnosis made early is essential for better results. As a potential diagnostic marker for SBP, ascetic calprotectin has demonstrated promise.
Objective: This study aimed to assess ascetic calprotectin levels in the diagnosis of SBP and its consequences in liver cirrhosis patients with HCV in Egypt.
Methods: This was a case-control hospital-based study on 120 cirrhotic Egyptian patients with ascites with different demographic data presented to the Hepatology Department of Shebin El-Kom Teaching Hospital and the Internal Medicine Department of Menoufia University Hospitals during the period from March 2023 till June 2024.
Results: Logistic regression analysis indicated ascetic calprotectin, ascetic TLC, urea, GFR, albumin and respiratory rate were the most significant independent factors associated with the mortality among the studied patients (p<0.05). While, other variables did not show significant relation with mortality rate (p>0.05).
Conclusion: Logistic regression analysis indicated ascetic calprotectin, ascetic TLC, urea, GFR, albumin and respiratory rate were the most significant independent factors associated with the mortality among the studied patients (p<0.05). While other variables did not significant relation with mortality rate (p>0.05).

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