The Effect of Platelet-Rich Plasma (PRP) on Wound Healing in High-Risk Patients Undergoing Abdominal Hysterectomy

Background: Hysterectomy remains one of the most commonly carried out operations in women’s health, often used not only for cancer-related cases but also to treat a wide range of non-cancerous conditions such as uterine fibroids, thickened uterine lining, tissue overgrowth, uterine sagging, irregular heavy bleeding, and early cervical changes.
Objective: To examine the effect of platelet-rich plasma (PRP) on wound healing in high-risk women undergoing abdominal hysterectomy, and compare wound complications—such as infection, wound opening, and delayed healing—between PRP and control groups. It also aimed to assess PRP’s impact on pain and patient satisfaction.
Patients and Methods: This randomized controlled trial enrolled 80 high-risk women undergoing abdominal hysterectomy, allocating them to either a PRP or control group. Wound healing, pain, and complications were assessed on postoperative days 1, 7, and 30.
Results: On day 7, the median pain score change from day 1 was -33.3% in the PRP group vs -15.48% in controls (p=0.006). On day 30, it was -80% in the PRP group vs 60% in controls (p < 0.001). No infections were reported on days 1 or 30. On day 7, infection occurred in 10% of PRP group vs 15% of controls (p=0.499). Readmission was needed in 5% of the PRP group vs 15% in controls (p=0.263).
Conclusion: PRP appears to improve wound healing after abdominal hysterectomy in high-risk women. PRP-treated patients showed better pain and healing scores, with fewer complications, suggesting its potential as a useful aid in recovery.