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A.Azeem, H., Abdel Aziz, A., Hashim, A., Ahmed, M. (2019). Glycemic State of Type 2 Diabetic Chronic Kidney Disease Patients after Vitamin D Replacement Therapy. The Egyptian Journal of Hospital Medicine, 76(6), 4274-4278. doi: 10.21608/ejhm.2019.43807
Haitham A.Azeem; Ayman Abdel Aziz; Alaa Mohammed Hashim; Mohammed Ahmed. "Glycemic State of Type 2 Diabetic Chronic Kidney Disease Patients after Vitamin D Replacement Therapy". The Egyptian Journal of Hospital Medicine, 76, 6, 2019, 4274-4278. doi: 10.21608/ejhm.2019.43807
A.Azeem, H., Abdel Aziz, A., Hashim, A., Ahmed, M. (2019). 'Glycemic State of Type 2 Diabetic Chronic Kidney Disease Patients after Vitamin D Replacement Therapy', The Egyptian Journal of Hospital Medicine, 76(6), pp. 4274-4278. doi: 10.21608/ejhm.2019.43807
A.Azeem, H., Abdel Aziz, A., Hashim, A., Ahmed, M. Glycemic State of Type 2 Diabetic Chronic Kidney Disease Patients after Vitamin D Replacement Therapy. The Egyptian Journal of Hospital Medicine, 2019; 76(6): 4274-4278. doi: 10.21608/ejhm.2019.43807

Glycemic State of Type 2 Diabetic Chronic Kidney Disease Patients after Vitamin D Replacement Therapy

Article 5, Volume 76, Issue 6, July 2019, Page 4274-4278  XML PDF (263.22 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.43807
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Authors
Haitham A.Azeem1; Ayman Abdel Aziz1; Alaa Mohammed Hashim2; Mohammed Ahmed1
1Internal Medicine Department, Faculty of Medicine, Al-Azhar University
2Clinical Pathology Department, Faculty of Medicine, Al-Azhar University
Abstract
Background: Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycaemia as a result of insulin deficiency, insulin resistance or both. Objective: To assess the impact of vitamin D replacement therapy on glycemic state in type 2 diabetic chronic kidney disease (CKD) patients. Patients and Methods: 70 patients previously diagnosed as type 2 DM (according to guidelines used by National Institute of Health USA) attending Al-Azhar Assuit University Hospital, internal medicine department and outpatient clinics was included in our study where vit. D was replaced in our groups and its impact on glycemic state was analyzed by bivariate and multivariate analyses. Results: Our study is a prospective study revealed a significant negative correlation between 25(OH)D levels and HbA1c values before and after vit. D replacement therapy. Conclusion: Vitamin D replacement therapy had a beneficial effect on glucose hemostasis via a significant reduction in HbA1c, this emphasizes the potential therapeutic implications of vitamin D supplementation as a promising preventative and therapeutic agent for improved glycemic control among type 2 DM patients with CKD
Keywords
HbA1c; Type 2 DM; Chronic Kidney Disease; Vit. D replacement; Intervention study
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