Skokr, A., Elshahed, A., Nosir, Y., AbdelSallam, M. (2019). Evaluation of Subclinical Left Ventricular Systolic Dysfunction Using Two Dimensional Speckle Tracking Echocardiography in Patients with Psoriasis. The Egyptian Journal of Hospital Medicine, 76(4), 3874-3881. doi: 10.21608/ejhm.2019.41566
Attia Morsy Skokr; Ahmed Rashad Elshahed; Youssef Fathy Nosir; Muhammad Abdullah AbdelSallam. "Evaluation of Subclinical Left Ventricular Systolic Dysfunction Using Two Dimensional Speckle Tracking Echocardiography in Patients with Psoriasis". The Egyptian Journal of Hospital Medicine, 76, 4, 2019, 3874-3881. doi: 10.21608/ejhm.2019.41566
Skokr, A., Elshahed, A., Nosir, Y., AbdelSallam, M. (2019). 'Evaluation of Subclinical Left Ventricular Systolic Dysfunction Using Two Dimensional Speckle Tracking Echocardiography in Patients with Psoriasis', The Egyptian Journal of Hospital Medicine, 76(4), pp. 3874-3881. doi: 10.21608/ejhm.2019.41566
Skokr, A., Elshahed, A., Nosir, Y., AbdelSallam, M. Evaluation of Subclinical Left Ventricular Systolic Dysfunction Using Two Dimensional Speckle Tracking Echocardiography in Patients with Psoriasis. The Egyptian Journal of Hospital Medicine, 2019; 76(4): 3874-3881. doi: 10.21608/ejhm.2019.41566
Evaluation of Subclinical Left Ventricular Systolic Dysfunction Using Two Dimensional Speckle Tracking Echocardiography in Patients with Psoriasis
1Departments of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
2Departments of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Abstract
Background: dermatologists as well as cardiologists have been studying cardiologic complications of psoriasis for many years. The reason for an increased cardiovascular morbidity in psoriasis seems to be the chronic systemic inflammatory process. Aim of the Work: to evaluate and detect subclinical LV dysfunction by 2D speckle tracking echocardiography in psoriatic patients. Patients and Methods: we selected 100 psoriatic patients (group 1) subclassified them into two equal subgroups; subgroup (1a) involved 50 psoriatic patients recently diagnosed and on topical treatment and subgroup (1b) included 50 psoriatic patients on systemic treatment. The study also included 30 apparently healthy individuals’ age and sex matched with the patients’ group represents the control group. Results: in comparison with healthy subjects, patients with psoriasis were found to have lower LV function using 2‐ D speckle tracking. The 2-D speckle method appears to be useful in the detection of LV systolic dysfunction in patients with psoriasis ،A statistically significant difference was found between sub-groups according to duration of Disease (years), psoriatic arthritis, PASI score and high sensitive CRP. Conclusion: the 2‐ D speckle tracking method appears to be useful in the detection of LV systolic dysfunction in patients with psoriasis. Subclinical left ventricular systolic dysfunction in psoriasis is linked with the inflammatory up-regulation, and enhanced pro-fibrotic activity may be involved in this process. These putative mechanisms may be responsible for the observed higher incidence of heart failure in this disease condition and should be considered as a potential target for preventive and therapeutic measures.
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