Hypo-Fractionation Radiotherapy in Breast Cancer Patients: Review Article

Document Type : Original Article

Abstract

In breast carcinoma management, radiation therapy (RT) is a necessary management. The typical therapeutic regimen for RT to the breast involves administering 25 fractions of 2.0 Gy per day over a five-week period. Breast cancer is more suitable for greater fraction sizes than squamous carcinomas, according to datasupporting the use of fewer fractions of more than 2 Gy per day (hypo-fractionation). Consequently, it may exhibit similarly high fractionation sensitivity to the dose-limiting normal tissues, such as muscle, subcutaneous tissues, skin, and ribs. This article examins the literature that supports the hypo-fractionated radiation efficacy in breast cancer treatment, explore the radiobiological rationale that is unique to carcinomas of breast, and present a case for the regimen implementation of shorter, hypo-fractionated RT sessions when radiation administered on breast.

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The Egyptian Journal of Hospital Medicine
Volume 98, Issue 1
January 2025
Pages 706-712

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