Home Articles List Article Information
The Egyptian Journal of Hospital Medicine
Journal Archive
Volume Volume 99 (2025)
Volume Volume 98 (2025)
Volume Volume 100 (2025)
Volume Volume 97 (2024)
Volume Volume 96 (2024)
Volume Volume 95 (2024)
Volume Volume 94 (2024)
Volume Volume 93 (2023)
Volume Volume 92 (2023)
Volume Volume 91 (2023)
Volume Volume 90 (2023)
Volume Volume 89 (2022)
Volume Volume 88 (2022)
Volume Volume 87 (2022)
Volume Volume 86 (2022)
Volume Volume 85 (2021)
Volume Volume 84 (2021)
Volume Volume 83 (2021)
Volume Volume 82 (2021)
Volume Volume 81 (2020)
Volume Volume 80 (2020)
Volume Volume 79 (2020)
Volume Volume 78 (2020)
Volume Volume 77 (2019)
Volume Volume 76 (2019)
Volume Volume 75 (2019)
Volume Volume 74 (2019)
Volume Volume 73 (2018)
Volume Volume 72 (2018)
Volume Volume 71 (2018)
Volume Volume 70 (2018)
Volume Volume 69 (2017)
Volume Volume 68 (2017)
Volume Volume 67 (2017)
Volume Volume 66 (2017)
Volume Volume 65 (2016)
Volume Volume 64 (2016)
Volume Volume 63 (2016)
Volume Volume 62 (2016)
Volume Volume 61 (2015)
Volume Volume 60 (2015)
Volume Volume 59 (2015)
Volume Volume 58 (2015)
Volume Volume 57 (2014)
Volume Volume 56 (2014)
Volume Volume 55 (2014)
Volume Volume 54 (2014)
Volume Volume 53 (2013)
Volume Volume 52 (2013)
Volume Volume 51 (2013)
Volume Volume 50 (2013)
Volume Volume 49 (2012)
Volume Volume 48 (2012)
Volume Volume 47 (2012)
Volume Volume 46 (2012)
Volume Volume 45 (2011)
Volume Volume 44 (2011)
Volume Volume 43 (2011)
Volume Volume 42 (2011)
Volume Volume 41 (2010)
Volume Volume 40 (2010)
Volume Volume 39 (2010)
Volume Volume 38 (2010)
Volume Volume 37 (2009)
Volume Volume 36 (2009)
Volume Volume 35 (2009)
Volume Volume 34 (2009)
Volume Volume 33 (2008)
Volume Volume 32 (2008)
Volume Volume 31 (2008)
Volume Volume 30 (2008)
Volume Volume 29 (2007)
Volume Volume 28 (2007)
Volume Volume 27 (2007)
Volume Volume 26 (2007)
Volume Volume 25 (2006)
Volume Volume 24 (2006)
Volume Volume 23 (2006)
Volume Volume 22 (2006)
Volume Volume 21 (2005)
Volume Volume 20 (2005)
Volume Volume 19 (2005)
Volume Volume 18 (2005)
Volume Volume 17 (2004)
Volume Volume 16 (2004)
Volume Volume 15 (2004)
Volume Volume 14 (2004)
Volume Volume 13 (2003)
Volume Volume 12 (2003)
Volume Volume 11 (2003)
Volume Volume 10 (2003)
Volume Volume 9 (2002)
Volume Volume 8 (2002)
Volume Volume 7 (2002)
Volume Volume 6 (2002)
Volume Volume 5 (2001)
Volume Volume 4 (2001)
Volume Volume 3 (2001)
Volume Volume 2 (2001)
Volume Volume 1 (2000)
(2024). Prognostic Value of Neuron-Specific Enolase (NSE) Biomarker in Neonates with Encephalopathy: Review Article. The Egyptian Journal of Hospital Medicine, 96(1), 2985-2990. doi: 10.21608/ejhm.2024.377462
. "Prognostic Value of Neuron-Specific Enolase (NSE) Biomarker in Neonates with Encephalopathy: Review Article". The Egyptian Journal of Hospital Medicine, 96, 1, 2024, 2985-2990. doi: 10.21608/ejhm.2024.377462
(2024). 'Prognostic Value of Neuron-Specific Enolase (NSE) Biomarker in Neonates with Encephalopathy: Review Article', The Egyptian Journal of Hospital Medicine, 96(1), pp. 2985-2990. doi: 10.21608/ejhm.2024.377462
Prognostic Value of Neuron-Specific Enolase (NSE) Biomarker in Neonates with Encephalopathy: Review Article. The Egyptian Journal of Hospital Medicine, 2024; 96(1): 2985-2990. doi: 10.21608/ejhm.2024.377462

Prognostic Value of Neuron-Specific Enolase (NSE) Biomarker in Neonates with Encephalopathy: Review Article

Article 97, Volume 96, Issue 1, July 2024, Page 2985-2990  XML PDF (300.34 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2024.377462
View on SCiNiTO View on SCiNiTO
Abstract
Background: Any illness that disrupts the central nervous system in the first few days of life can induce encephalopathy among neonates. This ailment can have a variety of causes. Of all the CSF neurobiochemical markers in babies with HIE, NSE has received the greatest amount of research. Up to four percent of all soluble brain proteins are NSE, a dimeric glycolytic enzyme. Neurons and neuroendocrine cells contain it primarily in their cytoplasm. When neurons suffer damage to their axons, NSE is found in high concentrations in their cytoplasm. Thus, it is sensitive for axonal injury and neuronal cell death and has a fairly high specificity for detecting axonal damage. Traditional terminology for neonatal encephalopathy (NE) has focused on hypoxic-ischemic encephalopathy, which occurs when an intrapartum incident causes perinatal hypoxia-ischemia.
Objective: The purpose of this study was to review the diagnostic value of the Neuron-Specific Enolase biomarker in the evaluation of early detection and its role in prognosis of neonatal encephalopathy.
Methods: In our search for information on NSE and its level in neonates with encephalopathy, we used Google Scholar, Science Direct, PubMed, and other internet databases. Additionally, the writers combed through relevant literature for references, however they only included researches that were either very recent or covering the years from 2010 to 2023.
Conclusion: Serum NSE is considered to be a reliable marker for the diagnosis of different stages of NE.
 
Keywords
Neonates; Encephalopathy; Neuron-Specific Enolase
Statistics
Article View: 123
PDF Download: 214