Relationship between Dementia and Oxidative Stress Among Elderly Men

doi:10.21608/ejhm.2024.374380

Home Articles List Article Information

|
|
|
How to cite
RIS EndNote BibTeX APA MLA Harvard Vancouver
|
Share

The Egyptian Journal of Hospital Medicine

Articles in Press

Current Issue

Journal Archive

Volume 99 (2025)

Volume 98 (2025)

Volume 97 (2024)

Volume 96 (2024)

Issue 1

Volume 95 (2024)

Volume 94 (2024)

Volume 93 (2023)

Volume 92 (2023)

Volume 91 (2023)

Volume 90 (2023)

Volume 89 (2022)

Volume 88 (2022)

Volume 87 (2022)

Volume 86 (2022)

Volume 85 (2021)

Volume 84 (2021)

Volume 83 (2021)

Volume 82 (2021)

Volume 81 (2020)

Volume 80 (2020)

Volume 79 (2020)

Volume 78 (2020)

Volume 77 (2019)

Volume 76 (2019)

Volume 75 (2019)

Volume 74 (2019)

Volume 73 (2018)

Volume 72 (2018)

Volume 71 (2018)

Volume 70 (2018)

Volume 69 (2017)

Volume 68 (2017)

Volume 67 (2017)

Volume 66 (2017)

Volume 65 (2016)

Volume 64 (2016)

Volume 63 (2016)

Volume 62 (2016)

Volume 61 (2015)

Volume 60 (2015)

Volume 59 (2015)

Volume 58 (2015)

Volume 57 (2014)

Volume 56 (2014)

Volume 55 (2014)

Volume 54 (2014)

Volume 53 (2013)

Volume 52 (2013)

Volume 51 (2013)

Volume 50 (2013)

Volume 49 (2012)

Volume 48 (2012)

Volume 47 (2012)

Volume 46 (2012)

Volume 45 (2011)

Volume 44 (2011)

Volume 43 (2011)

Volume 42 (2011)

Volume 41 (2010)

Volume 40 (2010)

Volume 39 (2010)

Volume 38 (2010)

Volume 37 (2009)

Volume 36 (2009)

Volume 35 (2009)

Volume 34 (2009)

Volume 33 (2008)

Volume 32 (2008)

Volume 31 (2008)

Volume 30 (2008)

Volume 29 (2007)

Volume 28 (2007)

Volume 27 (2007)

Volume 26 (2007)

Volume 25 (2006)

Volume 24 (2006)

Volume 23 (2006)

Volume 22 (2006)

Volume 21 (2005)

Volume 20 (2005)

Volume 19 (2005)

Volume 18 (2005)

Volume 17 (2004)

Volume 16 (2004)

Volume 15 (2004)

Volume 14 (2004)

Volume 13 (2003)

Volume 12 (2003)

Volume 11 (2003)

Volume 10 (2003)

Volume 9 (2002)

Volume 8 (2002)

Volume 7 (2002)

Volume 6 (2002)

Volume 5 (2001)

Volume 4 (2001)

Volume 3 (2001)

Volume 2 (2001)

Volume 1 (2000)

	Relationship between Dementia and Oxidative Stress Among Elderly Men
Article 74, Volume 96, Issue 1, July 2024, Page 2825-2832 PDF (389.54 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2024.374380
View on SCiNiTO
Abstract
Background: Dementia is a complex condition that affects the elderly and expands global health burdens. Numerous endogenous and external activities can result in the production of reactive oxygen and nitrogen species (RONS). Goal: To evaluate the association between oxidative stress markers and dementia in elderly men. Patients and Methods: A case-control study. Eighty males who were admitted to the Geriatrics and Gerontology Departments at Ain Shams University Hospitals as well as those who were recruited from the geriatric medicine outpatients' clinic were included in the study. The participants were split into two groups: a case group, which consisted of 40 adults with dementia, and a control group, which consisted of 40 participants without dementia. Participants underwent geriatric evaluations, and blood samples were obtained for measurement of oxidative stress blood levels as malondialdehyde (MDA), glutathione peroxidase enzyme (GPX), and total antioxidant capacity (TAC) Results: MDA blood levels were significantly higher in the case group, while GPX and TAC blood levels were significantly lower in the case group. According to statistical analysis, GPX with a cutoff point of 83.2 or lower, TAC with a cutoff point of 20.9 or lower, and MDA with a cutoff point of >82.5; all had high specificity and sensitivity for detecting dementia cases. Conclusion: Higher blood levels of MDA and lower blood levels of GPX and TAC in dementia cases compared to the control group indicate that oxidative stress plays a substantial role in the development of dementia.
Keywords
Antioxidants; Markers of oxidative stress; Dementia


Statistics Article View: 80 PDF Download: 128