(2024). The Effect of Elevated Serum Lactate Dehydrogenase Level on Survival of Newly Diagnosed Acute Myeloid Leukemia (AML) Patients. The Egyptian Journal of Hospital Medicine, 95(1), 1671-1678. doi: 10.21608/ejhm.2024.352944
. "The Effect of Elevated Serum Lactate Dehydrogenase Level on Survival of Newly Diagnosed Acute Myeloid Leukemia (AML) Patients". The Egyptian Journal of Hospital Medicine, 95, 1, 2024, 1671-1678. doi: 10.21608/ejhm.2024.352944
(2024). 'The Effect of Elevated Serum Lactate Dehydrogenase Level on Survival of Newly Diagnosed Acute Myeloid Leukemia (AML) Patients', The Egyptian Journal of Hospital Medicine, 95(1), pp. 1671-1678. doi: 10.21608/ejhm.2024.352944
The Effect of Elevated Serum Lactate Dehydrogenase Level on Survival of Newly Diagnosed Acute Myeloid Leukemia (AML) Patients. The Egyptian Journal of Hospital Medicine, 2024; 95(1): 1671-1678. doi: 10.21608/ejhm.2024.352944
The Effect of Elevated Serum Lactate Dehydrogenase Level on Survival of Newly Diagnosed Acute Myeloid Leukemia (AML) Patients
Background: Acute myeloid leukemia (AML) is a complex clonal malignancy that is impacted by both environmental variables and chromosomal anomalies. High tumour load and a poor prognosis are pathologically indicated by elevated white blood cell (WBC) count and lactate dehydrogenase (LDH) values. Objective: This study aimed to assess the clinical significance and prognostic value of serum LDH levels in AML patients. Patients and methods: At the Hematology Unit, Oncology Center, Mansoura University, we performed a retrospective analysis with 40 AML patients (19 males and 21 females) with a mean age of 44.3 ± 15.1 years. Hemoglobin was 8.5 g/dL, platelet count was 32.2 x 109/L, and median WBC was 31.5 x 109/L. Median serum LDH was 731.5 IU/L. The eligible patients had intermediate dose Cytarabine consolidation after receiving standard-intensity induction chemotherapy. Results: AML patients exhibited significantly higher LDH levels compared to healthy controls (215 IU/L; range 107-330) (P<0.001). Higher LDH levels correlated positively with WBC count and were notably associated with age over 60 and WBC > 50×109/L (P < 0.05). Patients whose LDH was higher than the median had an OS of two months, which was significantly shorter (range 1-6 months) versus 6 months (range 1-9 months) for those below the median (P=0.035). Univariable and multivariable analyses confirmed elevated LDH as a poor prognostic indicator for OS (P=0.036; HR=1.007, 95% CI, 1.005-1.011). Conclusion: High serum LDH level at diagnosis is an inexpensive, predictive marker of poor survival outcomes in patients with recently diagnosed AML, underscoring its importance in prognostic assessments.
View on SCiNiTO
Top