Bastawy, S., Ahmed, A. (2019). The Role of Serum Levels of Insulin-Like Growth Factor-1 and Brain-Derived Neurotrophic Factor in Predicting Recovery in Stroke. The Egyptian Journal of Hospital Medicine, 76(1), 3170-3175. doi: 10.21608/ejhm.2019.35089
Samah Bastawy; Ali Mahmoud Ahmed. "The Role of Serum Levels of Insulin-Like Growth Factor-1 and Brain-Derived Neurotrophic Factor in Predicting Recovery in Stroke". The Egyptian Journal of Hospital Medicine, 76, 1, 2019, 3170-3175. doi: 10.21608/ejhm.2019.35089
Bastawy, S., Ahmed, A. (2019). 'The Role of Serum Levels of Insulin-Like Growth Factor-1 and Brain-Derived Neurotrophic Factor in Predicting Recovery in Stroke', The Egyptian Journal of Hospital Medicine, 76(1), pp. 3170-3175. doi: 10.21608/ejhm.2019.35089
Bastawy, S., Ahmed, A. The Role of Serum Levels of Insulin-Like Growth Factor-1 and Brain-Derived Neurotrophic Factor in Predicting Recovery in Stroke. The Egyptian Journal of Hospital Medicine, 2019; 76(1): 3170-3175. doi: 10.21608/ejhm.2019.35089
The Role of Serum Levels of Insulin-Like Growth Factor-1 and Brain-Derived Neurotrophic Factor in Predicting Recovery in Stroke
1Department of Clinical Pathology, Faculty of Medicine, Helwan University, Cairo, Egypt
2Department of Neurology, Faculty of Medicine, Helwan University, Cairo, Egypt
Abstract
Background: Despite the neurotrophins like brain-derived neurotrophic factor and insulin-like growth factor-1 are thought to have important role in neurorehabilitation, the factors that affect these biomarkers are not well known. Objectives: We aimed to investigate the effect of maximal aerobic exercise on serum neurotrophins levels in patients with chronic stroke and to investigate the factors that affect their resting and exercise-associated levels. Patients and Methods: Potential factors of resting and exercise-related serum neurotrophins levels were studied among 35 patients with chronic stroke. Resting brain derived neurotrophic factor, resting insulin-like growth factor, exercisedependent change brain derived neurotrophic factor, and exercise- dependent change in insulin-like growth factor were studied using demographic, disease burden, and cardiometabolic factors. Results: Brain-derived neurotrophic factor did not change after exercise (p = 0.38) while insulin-like growth factor decreased (p = 0.001). Higher resting brain-derived neurotrophic factor was determined by greater lower extremity impairment (p = 0.004, r2 = 0.23). The greater response of brain-derived neurotrophic factor to exercise was determined by higher fluid intelligence (p = 0.01, r2 = 0.18). Resting insulin-like growth factor-1 was not changed by all of the studied factors. Conclusion: Resting and percent change in brain-derived neurotrophic factor were associated with cognitive and physical recovery after chronic stroke. On the other hands, insulin-like growth factor-1 was not useful in chronic stroke. Interestingly, fluid intelligence was positively associated with exercise-related rise in brain-derived neurotrophic factor.
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