Ghazy, M., El Mahdy, H., Mabrouk, M., Al-Farargy, M. (2019). Study of Serum Immunoglobulins G and M Levels in Children with Down Syndrome and Their Relation with Recurrent Lower Respiratory Tract Infection. The Egyptian Journal of Hospital Medicine, 75(5), 2900-2907. doi: 10.21608/ejhm.2019.33365
Manar Emad Aldeen Ghazy; Heba Said El Mahdy; Maaly Mohamed Mabrouk; Mohamed Shawky Al-Farargy. "Study of Serum Immunoglobulins G and M Levels in Children with Down Syndrome and Their Relation with Recurrent Lower Respiratory Tract Infection". The Egyptian Journal of Hospital Medicine, 75, 5, 2019, 2900-2907. doi: 10.21608/ejhm.2019.33365
Ghazy, M., El Mahdy, H., Mabrouk, M., Al-Farargy, M. (2019). 'Study of Serum Immunoglobulins G and M Levels in Children with Down Syndrome and Their Relation with Recurrent Lower Respiratory Tract Infection', The Egyptian Journal of Hospital Medicine, 75(5), pp. 2900-2907. doi: 10.21608/ejhm.2019.33365
Ghazy, M., El Mahdy, H., Mabrouk, M., Al-Farargy, M. Study of Serum Immunoglobulins G and M Levels in Children with Down Syndrome and Their Relation with Recurrent Lower Respiratory Tract Infection. The Egyptian Journal of Hospital Medicine, 2019; 75(5): 2900-2907. doi: 10.21608/ejhm.2019.33365
Study of Serum Immunoglobulins G and M Levels in Children with Down Syndrome and Their Relation with Recurrent Lower Respiratory Tract Infection
1Department of Pediatric Medicine, Faculty of Medicine, Tanta University, Egypt
2Department of Clinical Pathology, Faculty of Medicine, Tanta University, Egypt
Abstract
Background: Children with Down syndrome appear to be more likely susceptible to respiratory tract infections and it is an important cause of morbidity and mortality among them. Aim of the study: It was to investigate the relationship between levels of IgG and IgM in Down syndrome and recurrent lower respiratory tract infections. Subjects and Methods: This study was conducted on 40 children who were categorized into 2 groups: patient group, which includes children with Down syndrome patients presented with LRTIs, their karyotyping revealed trisomy 21 in all cases and their age range from 1 to 13 years. Control group, which includes 20 healthy children matched for sex and age with patient group. They were subjected to full history taking & thorough clinical examination, and they investigated for complete blood picture, C-reactive protein and serum immunoglobulins (IgG & IgM) using ELISA technique. Results: Plasma levels of immunoglobulin G (IgG) were elevated in Down syndrome with significant increase the frequency of lower respiratory tract infections and hospital admission. Plasma levels of immunoglobulin M (IgM) were decrease in down patients with significant increase in the frequency of lower respiratory tract infections and hospital admission. Conclusion: These findings suggest the importance of estimation and follow up of serum levels of IgG &Ig M in cases of Ds with recurrent respiratory tract infections.
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