Background: Children with Down syndrome appear to be more likely susceptible to respiratory tract infections and it is an important cause of morbidity and mortality among them. Aim of the study: It was to investigate the relationship between levels of IgG and IgM in Down syndrome and recurrent lower respiratory tract infections. Subjects and Methods: This study was conducted on 40 children who were categorized into 2 groups: patient group, which includes children with Down syndrome patients presented with LRTIs, their karyotyping revealed trisomy 21 in all cases and their age range from 1 to 13 years. Control group, which includes 20 healthy children matched for sex and age with patient group. They were subjected to full history taking & thorough clinical examination, and they investigated for complete blood picture, C-reactive protein and serum immunoglobulins (IgG & IgM) using ELISA technique. Results: Plasma levels of immunoglobulin G (IgG) were elevated in Down syndrome with significant increase the frequency of lower respiratory tract infections and hospital admission. Plasma levels of immunoglobulin M (IgM) were decrease in down patients with significant increase in the frequency of lower respiratory tract infections and hospital admission. Conclusion: These findings suggest the importance of estimation and follow up of serum levels of IgG &Ig M in cases of Ds with recurrent respiratory tract infections.
Ghazy, M. E. A., El Mahdy, H. S., Mabrouk, M. M., & Al-Farargy, M. S. (2019). Study of Serum Immunoglobulins G and M Levels in Children with Down Syndrome and Their Relation with Recurrent Lower Respiratory Tract Infection. The Egyptian Journal of Hospital Medicine, 75(5), 2900-2907. doi: 10.21608/ejhm.2019.33365
MLA
Manar Emad Aldeen Ghazy; Heba Said El Mahdy; Maaly Mohamed Mabrouk; Mohamed Shawky Al-Farargy. "Study of Serum Immunoglobulins G and M Levels in Children with Down Syndrome and Their Relation with Recurrent Lower Respiratory Tract Infection", The Egyptian Journal of Hospital Medicine, 75, 5, 2019, 2900-2907. doi: 10.21608/ejhm.2019.33365
HARVARD
Ghazy, M. E. A., El Mahdy, H. S., Mabrouk, M. M., Al-Farargy, M. S. (2019). 'Study of Serum Immunoglobulins G and M Levels in Children with Down Syndrome and Their Relation with Recurrent Lower Respiratory Tract Infection', The Egyptian Journal of Hospital Medicine, 75(5), pp. 2900-2907. doi: 10.21608/ejhm.2019.33365
VANCOUVER
Ghazy, M. E. A., El Mahdy, H. S., Mabrouk, M. M., Al-Farargy, M. S. Study of Serum Immunoglobulins G and M Levels in Children with Down Syndrome and Their Relation with Recurrent Lower Respiratory Tract Infection. The Egyptian Journal of Hospital Medicine, 2019; 75(5): 2900-2907. doi: 10.21608/ejhm.2019.33365
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