El-Garhy, I., Sabry, N., Abdel-Gahfar, M., Ahmed, A. (2019). Detection of Creatinine in Vaginal Fluid for Diagnosis of Preterm Premature Rupture of Membranes. The Egyptian Journal of Hospital Medicine, 75(5), 2894-2899. doi: 10.21608/ejhm.2019.33364
Ismail T. El-Garhy; Noha M. Sabry; Medhat A. Abdel-Gahfar; Ahmed A. Ahmed. "Detection of Creatinine in Vaginal Fluid for Diagnosis of Preterm Premature Rupture of Membranes". The Egyptian Journal of Hospital Medicine, 75, 5, 2019, 2894-2899. doi: 10.21608/ejhm.2019.33364
El-Garhy, I., Sabry, N., Abdel-Gahfar, M., Ahmed, A. (2019). 'Detection of Creatinine in Vaginal Fluid for Diagnosis of Preterm Premature Rupture of Membranes', The Egyptian Journal of Hospital Medicine, 75(5), pp. 2894-2899. doi: 10.21608/ejhm.2019.33364
El-Garhy, I., Sabry, N., Abdel-Gahfar, M., Ahmed, A. Detection of Creatinine in Vaginal Fluid for Diagnosis of Preterm Premature Rupture of Membranes. The Egyptian Journal of Hospital Medicine, 2019; 75(5): 2894-2899. doi: 10.21608/ejhm.2019.33364
Detection of Creatinine in Vaginal Fluid for Diagnosis of Preterm Premature Rupture of Membranes
1Department of Obstetrics and Gynecology, Faculty of Medicine – Al-Azhar University
2Department of Clinical Pathology, Faculty of Medicine – Al-Azhar University
Abstract
Background: to evaluate the role of vaginal fluid creatinine level in diagnosis of preterm prelabour rupture of membranes among patients giving history of amniotic fluid leak. Objectives: the aim of this study was to evaluate the reliability of vaginal fluid creatinine level in the vaginal fluid for diagnosis of prelabour premature rupture of membranes. Patients and Methods: 100 pregnant women with gestational age 24: 37 weeks gestation participated in the present study divided into 2 groups. Group I (confirmed PROM group) & group II (control non-PROM group). All patients underwent a sterile speculum examination for detection of amniotic fluid pooling in the posterior vaginal fornix followed by taking 3ml from vaginal fluid. Creatinine measurement was done using ELISA. Results: The mean creatinine levels in vaginal fluid in group (I) & group (II) were.70 ± 0.88 and.04 ± 0.18 mIU/mL respectively. The difference was statistically significant (P value < 0.001). With creatinine cut-off value of 0.25 mIU/ml, the sensitivity & specificity in confirming PROM were 72 and 94% respectively. Conclusion: Creatinine level was significantly higher in pregnant women with definite PROM. Therefore, vaginal fluid creatinine can be used as an easy, rapid, reliable and non-invasive test for confirming the diagnosis of PROM and can be used as an adjunctive test in equivocal cases.