Home Articles List Article Information
The Egyptian Journal of Hospital Medicine
Journal Archive
Volume Volume 97 (2024)
Volume Volume 96 (2024)
Volume Volume 95 (2024)
Volume Volume 94 (2024)
Volume Volume 93 (2023)
Volume Volume 92 (2023)
Volume Volume 91 (2023)
Volume Volume 90 (2023)
Volume Volume 89 (2022)
Volume Volume 88 (2022)
Volume Volume 87 (2022)
Volume Volume 86 (2022)
Volume Volume 85 (2021)
Volume Volume 84 (2021)
Volume Volume 83 (2021)
Volume Volume 82 (2021)
Volume Volume 81 (2020)
Volume Volume 80 (2020)
Volume Volume 79 (2020)
Volume Volume 78 (2020)
Volume Volume 77 (2019)
Volume Volume 76 (2019)
Volume Volume 75 (2019)
Volume Volume 74 (2019)
Volume Volume 73 (2018)
Volume Volume 72 (2018)
Volume Volume 71 (2018)
Volume Volume 70 (2018)
Volume Volume 69 (2017)
Volume Volume 68 (2017)
Volume Volume 67 (2017)
Volume Volume 66 (2017)
Volume Volume 65 (2016)
Volume Volume 64 (2016)
Volume Volume 63 (2016)
Volume Volume 62 (2016)
Volume Volume 61 (2015)
Volume Volume 60 (2015)
Volume Volume 59 (2015)
Volume Volume 58 (2015)
Volume Volume 57 (2014)
Volume Volume 56 (2014)
Volume Volume 55 (2014)
Volume Volume 54 (2014)
Volume Volume 53 (2013)
Volume Volume 52 (2013)
Volume Volume 51 (2013)
Volume Volume 50 (2013)
Volume Volume 49 (2012)
Volume Volume 48 (2012)
Volume Volume 47 (2012)
Volume Volume 46 (2012)
Volume Volume 45 (2011)
Volume Volume 44 (2011)
Volume Volume 43 (2011)
Volume Volume 42 (2011)
Volume Volume 41 (2010)
Volume Volume 40 (2010)
Volume Volume 39 (2010)
Volume Volume 38 (2010)
Volume Volume 37 (2009)
Volume Volume 36 (2009)
Volume Volume 35 (2009)
Volume Volume 34 (2009)
Volume Volume 33 (2008)
Volume Volume 32 (2008)
Volume Volume 31 (2008)
Volume Volume 30 (2008)
Volume Volume 29 (2007)
Volume Volume 28 (2007)
Volume Volume 27 (2007)
Volume Volume 26 (2007)
Volume Volume 25 (2006)
Volume Volume 24 (2006)
Volume Volume 23 (2006)
Volume Volume 22 (2006)
Volume Volume 21 (2005)
Volume Volume 20 (2005)
Volume Volume 19 (2005)
Volume Volume 18 (2005)
Volume Volume 17 (2004)
Volume Volume 16 (2004)
Volume Volume 15 (2004)
Volume Volume 14 (2004)
Volume Volume 13 (2003)
Volume Volume 12 (2003)
Volume Volume 11 (2003)
Volume Volume 10 (2003)
Volume Volume 9 (2002)
Volume Volume 8 (2002)
Volume Volume 7 (2002)
Volume Volume 6 (2002)
Volume Volume 5 (2001)
Volume Volume 4 (2001)
Volume Volume 3 (2001)
Volume Volume 2 (2001)
Volume Volume 1 (2000)
El-Shaer, N., Abd El-Azez, A. (2019). Effect of Buspirone on the Histological and Immunohistochemical Alterations on Pancreas of Fetuses in Pregnant Rats. The Egyptian Journal of Hospital Medicine, 75(3), 2481-2491. doi: 10.21608/ejhm.2019.30966
Nahla H. El-Shaer; Asmaa M. Abd El-Azez. "Effect of Buspirone on the Histological and Immunohistochemical Alterations on Pancreas of Fetuses in Pregnant Rats". The Egyptian Journal of Hospital Medicine, 75, 3, 2019, 2481-2491. doi: 10.21608/ejhm.2019.30966
El-Shaer, N., Abd El-Azez, A. (2019). 'Effect of Buspirone on the Histological and Immunohistochemical Alterations on Pancreas of Fetuses in Pregnant Rats', The Egyptian Journal of Hospital Medicine, 75(3), pp. 2481-2491. doi: 10.21608/ejhm.2019.30966
El-Shaer, N., Abd El-Azez, A. Effect of Buspirone on the Histological and Immunohistochemical Alterations on Pancreas of Fetuses in Pregnant Rats. The Egyptian Journal of Hospital Medicine, 2019; 75(3): 2481-2491. doi: 10.21608/ejhm.2019.30966

Effect of Buspirone on the Histological and Immunohistochemical Alterations on Pancreas of Fetuses in Pregnant Rats

Article 23, Volume 75, Issue 3, April 2019, Page 2481-2491  XML PDF (657.2 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.30966
View on SCiNiTO View on SCiNiTO
Authors
Nahla H. El-Shaer email 1; Asmaa M. Abd El-Azez2
1Zoology Department, Faculty of Science, Zagazig University, Egypt
2Zoology Department, Faculty of Science, Al-Azhar University, Egypt
Abstract
Aim of the work: Buspar drug(buspirone) is an antianxiety agent for the treatment of anxiety, and there are no adequate studies of Buspar in pregnant women which made this issue an exciting research area; so that our aim was to study the effects of buspirone on the structure of pancreatic tissue of the maternally treated rat fetuses. Material and methods: Buspirone hydrochloride tablets were obtained from Beecham, Haram, Giza, Egypt. Animals were divided into three groups (Ten pregnant rats in each group). Group I: (The control group) pregnant rats administrated orally distilled water only; Group II: pregnant rats were given oral dosages of buspirone hydrochloride at a dose level of 0.27 mg/ 100g b.w./day, daily for 15 days from the 6 th day to the 20 th day of gestation; Group III: pregnant rats were treated with the same manner with buspirone hydrochloride at a dose level of 0.41 mg/ 100g b.w./ day for 15 days from the 6 th to the 20 th day of gestation. Samples were taken from pregnant rats of all groups which sacrificed at 20 th day of gestation and fetuses were picked out for histological, histochemical and immunohistochemical studies for pancreatic anti-insulin and caspase-3 monoclonal antibody markers. Results: Treatment of pregnant rats with buspirone showed histopathological alterations in the pancreas of their fetuses; these alterations were well marked in the high dose maternally treated fetuses, and resulted in deformity in the pancreatic tissues. Conclusion: The present study showed that administration of buspirone may result in several histological and immunohistochemical deformity in the fetal pancreatic tissues.
Keywords
Buspar drug; Caspase-3; histopathology; Immunohistochemical and fetal pancreas
Statistics
Article View: 422
PDF Download: 464