Home Articles List Article Information
The Egyptian Journal of Hospital Medicine
Journal Archive
Volume Volume 99 (2025)
Volume Volume 98 (2025)
Volume Volume 100 (2025)
Volume Volume 97 (2024)
Volume Volume 96 (2024)
Volume Volume 95 (2024)
Volume Volume 94 (2024)
Volume Volume 93 (2023)
Volume Volume 92 (2023)
Volume Volume 91 (2023)
Volume Volume 90 (2023)
Volume Volume 89 (2022)
Volume Volume 88 (2022)
Volume Volume 87 (2022)
Volume Volume 86 (2022)
Volume Volume 85 (2021)
Volume Volume 84 (2021)
Volume Volume 83 (2021)
Volume Volume 82 (2021)
Volume Volume 81 (2020)
Volume Volume 80 (2020)
Volume Volume 79 (2020)
Volume Volume 78 (2020)
Volume Volume 77 (2019)
Volume Volume 76 (2019)
Volume Volume 75 (2019)
Volume Volume 74 (2019)
Volume Volume 73 (2018)
Volume Volume 72 (2018)
Volume Volume 71 (2018)
Volume Volume 70 (2018)
Volume Volume 69 (2017)
Volume Volume 68 (2017)
Volume Volume 67 (2017)
Volume Volume 66 (2017)
Volume Volume 65 (2016)
Volume Volume 64 (2016)
Volume Volume 63 (2016)
Volume Volume 62 (2016)
Volume Volume 61 (2015)
Volume Volume 60 (2015)
Volume Volume 59 (2015)
Volume Volume 58 (2015)
Volume Volume 57 (2014)
Volume Volume 56 (2014)
Volume Volume 55 (2014)
Volume Volume 54 (2014)
Volume Volume 53 (2013)
Volume Volume 52 (2013)
Volume Volume 51 (2013)
Volume Volume 50 (2013)
Volume Volume 49 (2012)
Volume Volume 48 (2012)
Volume Volume 47 (2012)
Volume Volume 46 (2012)
Volume Volume 45 (2011)
Volume Volume 44 (2011)
Volume Volume 43 (2011)
Volume Volume 42 (2011)
Volume Volume 41 (2010)
Volume Volume 40 (2010)
Volume Volume 39 (2010)
Volume Volume 38 (2010)
Volume Volume 37 (2009)
Volume Volume 36 (2009)
Volume Volume 35 (2009)
Volume Volume 34 (2009)
Volume Volume 33 (2008)
Volume Volume 32 (2008)
Volume Volume 31 (2008)
Volume Volume 30 (2008)
Volume Volume 29 (2007)
Volume Volume 28 (2007)
Volume Volume 27 (2007)
Volume Volume 26 (2007)
Volume Volume 25 (2006)
Volume Volume 24 (2006)
Volume Volume 23 (2006)
Volume Volume 22 (2006)
Volume Volume 21 (2005)
Volume Volume 20 (2005)
Volume Volume 19 (2005)
Volume Volume 18 (2005)
Volume Volume 17 (2004)
Volume Volume 16 (2004)
Volume Volume 15 (2004)
Volume Volume 14 (2004)
Volume Volume 13 (2003)
Volume Volume 12 (2003)
Volume Volume 11 (2003)
Volume Volume 10 (2003)
Volume Volume 9 (2002)
Volume Volume 8 (2002)
Volume Volume 7 (2002)
Volume Volume 6 (2002)
Volume Volume 5 (2001)
Volume Volume 4 (2001)
Volume Volume 3 (2001)
Volume Volume 2 (2001)
Volume Volume 1 (2000)
Al-Zahraa, F., AbdelHay, N., Adel, S., Diab, H., Mansour, A. (2023). Can Upregulation of CXCR3 By Phototherapy Improve Vitiligo? It’s Role in Chronicity. The Egyptian Journal of Hospital Medicine, 92(1), 5595-5603. doi: 10.21608/ejhm.2023.306171
Fatma Al-Zahraa; Nesma Hussein AbdelHay; Seham Adel; Heba Mahmoud Diab; Amal Mansour. "Can Upregulation of CXCR3 By Phototherapy Improve Vitiligo? It’s Role in Chronicity". The Egyptian Journal of Hospital Medicine, 92, 1, 2023, 5595-5603. doi: 10.21608/ejhm.2023.306171
Al-Zahraa, F., AbdelHay, N., Adel, S., Diab, H., Mansour, A. (2023). 'Can Upregulation of CXCR3 By Phototherapy Improve Vitiligo? It’s Role in Chronicity', The Egyptian Journal of Hospital Medicine, 92(1), pp. 5595-5603. doi: 10.21608/ejhm.2023.306171
Al-Zahraa, F., AbdelHay, N., Adel, S., Diab, H., Mansour, A. Can Upregulation of CXCR3 By Phototherapy Improve Vitiligo? It’s Role in Chronicity. The Egyptian Journal of Hospital Medicine, 2023; 92(1): 5595-5603. doi: 10.21608/ejhm.2023.306171

Can Upregulation of CXCR3 By Phototherapy Improve Vitiligo? It’s Role in Chronicity

Article 19, Volume 92, Issue 1, July 2023, Page 5595-5603  XML PDF (582.04 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2023.306171
View on SCiNiTO View on SCiNiTO
Authors
Fatma Al-Zahraa; Nesma Hussein AbdelHay email orcid ; Seham Adel; Heba Mahmoud Diab; Amal Mansour
Faculty of Medicine, Ain Shams University
Abstract
Background: Vitiligo is melanocyte death that is affected by oxidative stress which elevated levels of reactive oxygen species can elicit an immune response, and ultimately cause melanocytic death.
Objective: The current study aimed to investigate the impact of Narrowband Ultraviolet B (NBUVB) and excimer laser phototherapy on C-X-C motif chemokine receptor 3B expression in vitiligo patients and its impact on vitiligo improvement.
Patients and methods: CXCR3B mRNA expression was measured in skin of25 patients suffering from non-segmental vitiligo before and after generalized ‘NBUVB’ and targeted phototherapy ‘Excimer laser’. All biopsies were kept in - 80C till RNA extraction that was performed utilizing QIAGEN RNeasy Little Pack, QuantiTect Switch Record Unit and QuantiNova SYBR Green PCR Unit.
Results: After phototherapy patients with vitiligo had higher CXCR3B mRNA levels, in addition, this was higher in excimer bunch treatment than NBUVB.
Conclusion: Such findings draw attention to CXCR3B as an inherited abnormality in vitiligo patients' skin and raise concerns about its potential contributions in maintaining vitiligo or triggering relapses & chronicity.
 
 
Keywords
Vitiligo; CXCR3; phototherapy; mRNA; PCR; Intervention study; Ain Shams University
Statistics
Article View: 240
PDF Download: 463