Can Upregulation of CXCR3 By Phototherapy Improve Vitiligo? It’s Role in Chronicity

Document Type : Original Article

Authors

Faculty of Medicine, Ain Shams University

Abstract

Background: Vitiligo is melanocyte death that is affected by oxidative stress which elevated levels of reactive oxygen species can elicit an immune response, and ultimately cause melanocytic death.
Objective: The current study aimed to investigate the impact of Narrowband Ultraviolet B (NBUVB) and excimer laser phototherapy on C-X-C motif chemokine receptor 3B expression in vitiligo patients and its impact on vitiligo improvement.
Patients and methods: CXCR3B mRNA expression was measured in skin of25 patients suffering from non-segmental vitiligo before and after generalized ‘NBUVB’ and targeted phototherapy ‘Excimer laser’. All biopsies were kept in - 80C till RNA extraction that was performed utilizing QIAGEN RNeasy Little Pack, QuantiTect Switch Record Unit and QuantiNova SYBR Green PCR Unit.
Results: After phototherapy patients with vitiligo had higher CXCR3B mRNA levels, in addition, this was higher in excimer bunch treatment than NBUVB.
Conclusion: Such findings draw attention to CXCR3B as an inherited abnormality in vitiligo patients' skin and raise concerns about its potential contributions in maintaining vitiligo or triggering relapses & chronicity.
 
 

Keywords

The Egyptian Journal of Hospital Medicine
Volume 92, Issue 1
July 2023
Pages 5595-5603

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