Abdelghany, A., Abohashim, M., Aemmaar, W., Elsayed, R., saleh, S. (2023). Predictive Value of Follicular Stimulating Hormone on Luteinizing Hormone Ratio for Ovarian Response to Simple Ovulation Induction in Patients with Polycystic Ovarian Syndrome. The Egyptian Journal of Hospital Medicine, 92(1), 5474-5477. doi: 10.21608/ejhm.2023.305784
Amany Abdelghany; Mohamed Fathy Abohashim; Wisal Ammar Emran Aemmaar; Reham A. Elsayed; shahenda ahmed saleh. "Predictive Value of Follicular Stimulating Hormone on Luteinizing Hormone Ratio for Ovarian Response to Simple Ovulation Induction in Patients with Polycystic Ovarian Syndrome". The Egyptian Journal of Hospital Medicine, 92, 1, 2023, 5474-5477. doi: 10.21608/ejhm.2023.305784
Abdelghany, A., Abohashim, M., Aemmaar, W., Elsayed, R., saleh, S. (2023). 'Predictive Value of Follicular Stimulating Hormone on Luteinizing Hormone Ratio for Ovarian Response to Simple Ovulation Induction in Patients with Polycystic Ovarian Syndrome', The Egyptian Journal of Hospital Medicine, 92(1), pp. 5474-5477. doi: 10.21608/ejhm.2023.305784
Abdelghany, A., Abohashim, M., Aemmaar, W., Elsayed, R., saleh, S. Predictive Value of Follicular Stimulating Hormone on Luteinizing Hormone Ratio for Ovarian Response to Simple Ovulation Induction in Patients with Polycystic Ovarian Syndrome. The Egyptian Journal of Hospital Medicine, 2023; 92(1): 5474-5477. doi: 10.21608/ejhm.2023.305784
Predictive Value of Follicular Stimulating Hormone on Luteinizing Hormone Ratio for Ovarian Response to Simple Ovulation Induction in Patients with Polycystic Ovarian Syndrome
Background: Polycystic ovary syndrome (PCOS) is considered the most frequentovulatory disorder. PCOS often has a problem in (GnRH) release, with increase in the pituitary secretion of (LH) hormone and high LH/FSH ratio. Objective: The current study aimed at detecting the predictive level of LH/FSH ratio for the ovarian response, pregnancy and miscarriage rates in PCOS patients underwent mild ovarian stimulation. Patients and methods: A prospective cohort study was conducted in Gynaecology and Obstetrics Department, Zagazig University Hospitals. The study included PCOS womenaged from 20 to 37 years, with at least 1 year of infertility, and normal semen analysis. The exclusion criteria were pelvic surgery and/or pathology. Cycle day 2-5 Serum LH and FSH were measured. Transvaginal ultrasound was done on cycle day 2-3 to prove quiescent ovaries, letrozole (2.5-5mg) was started from day 2-3 for successive 5 days with/without HMG (75-150IU/d) then follicular tracking was done till 1-3 follicles reached ≥18 mm upon which ovulation trigger was given. Results: A total63 infertile women were included in the study. The mean age was 24.81 (SD 2.83) years, the mean BMI 30.65 (SD 6.58) Kg /m2. Basal FSH, LH level, and LH/FSH ratio ranged from 1.9-11.9 mIu/ml, 2.34-21 mIu/ml and 0.37-4.63, respectively. ROC curve analysis showed LH/FSH ratio to be non-useful predictor of ovarian response, occurrence of pregnancy or miscarriage in PCOS patients underwent simple ovarian induction, AUC (0.51, 0.64 and 0.69 respectively). Conclusion: LH/FSH ratio seems to have no role in prediction of stimulated cycle outcome.