Epithelial-Mesenchymal Transition Axis Lin 28, ARID1A, And ELF3 As A Novel Prognostic Triad in Invasive Ductal Breast Carcinoma

Hanafy, Sabah Mohamed; Fayad, Eman Elsayed; Alabiad, Mohamed Ali

doi:10.21608/ejhm.2023.301785

Epithelial-Mesenchymal Transition Axis Lin 28, ARID1A, And ELF3 As A Novel Prognostic Triad in Invasive Ductal Breast Carcinoma

Document Type : Original Article

Authors

Faculty of Medicine, Zagazig University, Zagazig, Egypt

10.21608/ejhm.2023.301785

Abstract

Background: Breast cancer is the most often identified cancer in women and considered the second principal cause of cancer death among all women.
Objective: The aim of the study was to evaluate the relationship between Epithelial-mesenchymal Transition markers Lin 28, ARID1A, and ELF3 and the clinicopathological parameters and outcomes in invasive ductal breast carcinoma.
Materials and Methods: This retrospective study was on 120 breast cancer cases by evaluation the immunohistochemical expression of Lin 28, ARID1A, and ELF3 and correlation their expression with the clinicopathological and the outcome parameters of the patients.
Results: Lin 28, ARID1A and ELF3 expression statistically significant correlation with tumor size, with a high KI67 index, positive ER/ PR expression and Her-2/neu, high grade lymph node metastasis, lymph vascular invasion, perineural invasion and mortality.
Conclusions: Overexpression of the mesenchymal stem cell markers (ARID1A-1 and Lin23) and a decrease in the expression of the epithelial markers (ELF3) were strongly related poor prognostic and clinicopathological parameters of invasive ductal breast cancer.

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