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Shedeed, S., Ibrahim, Y., Ahmed, A., Elhewala, A. (2023). Serum Catestatin as a Novel Biomarker of Cardiometabolic Risk among Diabetic Children. The Egyptian Journal of Hospital Medicine, 91(1), 4903-4909. doi: 10.21608/ejhm.2023.301576
Soad Shedeed; Yasmeen El-Sayed Ibrahim; Alshymaa A. Ahmed; Ahmed Elhewala. "Serum Catestatin as a Novel Biomarker of Cardiometabolic Risk among Diabetic Children". The Egyptian Journal of Hospital Medicine, 91, 1, 2023, 4903-4909. doi: 10.21608/ejhm.2023.301576
Shedeed, S., Ibrahim, Y., Ahmed, A., Elhewala, A. (2023). 'Serum Catestatin as a Novel Biomarker of Cardiometabolic Risk among Diabetic Children', The Egyptian Journal of Hospital Medicine, 91(1), pp. 4903-4909. doi: 10.21608/ejhm.2023.301576
Shedeed, S., Ibrahim, Y., Ahmed, A., Elhewala, A. Serum Catestatin as a Novel Biomarker of Cardiometabolic Risk among Diabetic Children. The Egyptian Journal of Hospital Medicine, 2023; 91(1): 4903-4909. doi: 10.21608/ejhm.2023.301576

Serum Catestatin as a Novel Biomarker of Cardiometabolic Risk among Diabetic Children

Article 178, Volume 91, Issue 1, April 2023, Page 4903-4909  XML PDF (594.74 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2023.301576
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Authors
Soad Shedeed; Yasmeen El-Sayed Ibrahim; Alshymaa A. Ahmed; Ahmed Elhewala
Abstract
Background: Along with decreased sympatho-adrenal flow, catestatin has a number of cardiovascular effects. Reduced plasma catestatin levels could be a sign of a predisposition to develop metabolic and hypertensive diseases.
Aim and objectives: To assess the function of catestatin in cardiometabolic risk assessment among diabetic children.
Subjects and methods:  This case-control study was carried out on 108 children at Pediatrics Department, Zagazig University Hospital. Children were divided into 2 groups: (Group A): Case group 54 children with diabetes, (Group B): Control group 54 apparent healthy children at same sex and age. Every infant was subjected to serum catestatin concentrations measurement using ELISA Kit.
Result: Median Catestatin in diabetic group was 8.35 ng/ml (6.16 – 17.41) while that for Control group was 11.19 ng/dl(7.42 -16.56), the difference was statistically significant(p < 0.05).
Conclusion: Serum Catestatin was related to diabetes and it cannot be considered as a good biomarker of cardio metabolic risk among diabetic children. Further larger scale studies are needed to confirm our results.
 
Keywords
heart; blood pressure; coronary artery disease; and metabolic; catestatin
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