Wafa, Y., ALKhouly, M., Mosalam, R. (2019). Role of Low Dose Sildenafil in Improvement of Implantation Rate in Case of Recurrent ICSI failure. The Egyptian Journal of Hospital Medicine, 75(2), 2173-2182. doi: 10.21608/ejhm.2019.30105
Yahia A. Wafa; Mohammed Moh. ALKhouly; Reham M. Salah Abdelsalam Mosalam. "Role of Low Dose Sildenafil in Improvement of Implantation Rate in Case of Recurrent ICSI failure". The Egyptian Journal of Hospital Medicine, 75, 2, 2019, 2173-2182. doi: 10.21608/ejhm.2019.30105
Wafa, Y., ALKhouly, M., Mosalam, R. (2019). 'Role of Low Dose Sildenafil in Improvement of Implantation Rate in Case of Recurrent ICSI failure', The Egyptian Journal of Hospital Medicine, 75(2), pp. 2173-2182. doi: 10.21608/ejhm.2019.30105
Wafa, Y., ALKhouly, M., Mosalam, R. Role of Low Dose Sildenafil in Improvement of Implantation Rate in Case of Recurrent ICSI failure. The Egyptian Journal of Hospital Medicine, 2019; 75(2): 2173-2182. doi: 10.21608/ejhm.2019.30105
Role of Low Dose Sildenafil in Improvement of Implantation Rate in Case of Recurrent ICSI failure
Department of Obstetrics and Gynecology, Al-Azhar University, Cairo, Egypt
Abstract
Background: Infertile couples to have healthy children are one of primary tasks of assisted reproductive technologies. In order to fulfill these tasks, reproductive medicine constantly needs to obtain information on physiology and pathophysiology of infertility and to develop efficient strategies for ovarian hyper-stimulation. Objectives: Aim of the current Work was to evaluate the efficacy of oral sildenafil citrate 25 mg on pregnancy outcome, endometrial thickness, pattern and uterine arteries Doppler blood flow in patients with 3 or more concoctive unexplained recurrent IVF/ICSI implantation failure. Patients and Methods: This prospective, randomized, double blinded study included a total of seventy patients undergoing ICSI trial attending at the University Maternity Hospital IVF\ICSI unit. The included subjects were randomly allocated into two groups: Group I (study group): included 35 women with recurrent ICSI implantation failure with another trial of ICSI using the standard drugs and technique with the addition of sildenafil 25 mg orally twice daily. Group II (control group): included 35 women with recurrent ICSI implantation failure with another trial of ICSI using the standard drugs and technique (control group). Results: The statistical comparison between group I (Sildenafil Citrate) and group II (control) regarding endometrial thickness showed non significant differences before and significant differences after 21days of administration of Sildenafil Citrate. The statistical comparison in patients in group I (Sildenafil Citrate) regarding Pulsatility index, Resistance index and Systolic/ diastolic ratio showed significant differences of these parameters. Conclusion: It could be concluded from this study that adding of sildenafil citrate 25 mg orally twice daily for 21 days to patients with unexplained recurrent ICSI implantation failure, increase in pregnancy rate.
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