The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia

Khalifa, Abd-Alsameea Hassan; Farahat, Mohamed Mohamed Ibrahim; Mohamed, Ahmed Fadel Abdel Hameed

doi:10.21608/ejhm.2019.29719

The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia

Document Type : Original Article

Authors

Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

10.21608/ejhm.2019.29719

Abstract

Background: Many studies hypothesized a strong relation between vitamin D level during pregnancy and the frequency of recurrent preeclampsia (PE). Objectives: The aim of the current study was to determine the effect of vitamin D supplement on reducing the probability of recurrent preeclampsia in pregnant women with history of preeclampsia. Patients and Methods: The study population included 50 women having a history of preeclampsia in previous pregnancies. They were referred to the obstetrical clinic in Diarb Negm Centeral Hospital in Diarb Negm City, for prenatal care. Women were classified into two groups, the first one (I) received 25-hydroxy vitamin D supplements and the other (II) received placebo. Results: Eight patients had pre-eclampsia in group II (34.8%) while in group I only 4 patients had preeclampsia (16%) (p=0.133). There were no significant statistical differences between the two groups according to pre-eclampsia incidence. The mean vitamin D level was 25.72 ± 7.69 and 28.33 ± 7.40 among patients without and with preeclampsia respectively. (p=0.309) there were no significant relation between the preeclampsia incidence and vitamin D level. Conclusion: vitamin D supplement may not have a role in prevention of preeclampsia recurrence.

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