Elhendawy, R., Elghoneimy, S., Elnemr, S., Salem, A., Abdelkader, A. (2023). Predictive Value of Neutrophil to Lymphocyte Ratio Combined with C-Reactive Protein for Diagnosis of Spontaneous Bacterial Peritonitis among Cirrhotic Patients. The Egyptian Journal of Hospital Medicine, 91(1), 4380-4386. doi: 10.21608/ejhm.2023.296396
Ramy I. Elhendawy; Salama M. Elghoneimy; Sahar A. Elnemr; Aya A. Salem; Abeer H. Abdelkader. "Predictive Value of Neutrophil to Lymphocyte Ratio Combined with C-Reactive Protein for Diagnosis of Spontaneous Bacterial Peritonitis among Cirrhotic Patients". The Egyptian Journal of Hospital Medicine, 91, 1, 2023, 4380-4386. doi: 10.21608/ejhm.2023.296396
Elhendawy, R., Elghoneimy, S., Elnemr, S., Salem, A., Abdelkader, A. (2023). 'Predictive Value of Neutrophil to Lymphocyte Ratio Combined with C-Reactive Protein for Diagnosis of Spontaneous Bacterial Peritonitis among Cirrhotic Patients', The Egyptian Journal of Hospital Medicine, 91(1), pp. 4380-4386. doi: 10.21608/ejhm.2023.296396
Elhendawy, R., Elghoneimy, S., Elnemr, S., Salem, A., Abdelkader, A. Predictive Value of Neutrophil to Lymphocyte Ratio Combined with C-Reactive Protein for Diagnosis of Spontaneous Bacterial Peritonitis among Cirrhotic Patients. The Egyptian Journal of Hospital Medicine, 2023; 91(1): 4380-4386. doi: 10.21608/ejhm.2023.296396
Predictive Value of Neutrophil to Lymphocyte Ratio Combined with C-Reactive Protein for Diagnosis of Spontaneous Bacterial Peritonitis among Cirrhotic Patients
Background: A serious problem for cirrhotic individuals is spontaneous bacterial peritonitis (SBP). Clinical significance of SBP's C-reactive protein (CRP) as well as neutrophil-to-lymphocyte ratio (NLR) have been discovered using varying threshold levels. Objective: The aim of the current work was to assess the validity of diagnostic paracentesis with the use of combined blood NLR and CRP as a non-invasive predictor for early diagnosis of SBP. Patients and Methods: This case control study included a total of 60 cirrhotic decompensated patients, admitted at Department of Tropical Medicine, Zagazig University Hospitals. Patients were categorized into two groups (30 each) according to neutrophil count in Ascitic fluid; Group I with SBP and Group II free from SBP. Both NLR and CRP were assessed among all subjects. Results: NLR was statistically significant higher in SBP group. A cut-off value of blood NLR >2.9 on ROC curve had a specificity of 88% as well as sensitivity of 95% for SBP diagnosis in cirrhotic patients. CRP level differed significantly among cirrhotic patients diagnosed with SBP. A cut-off >15 mg/L had a sensitivity and specificity of 85% and 90 % respectively in diagnosing SBP in cirrhotic patients. Combination NLR and CRP had a cut-off >22.6 mg/L, had a sensitivity and specificity of 86%, 91 % respectively in SBP diagnosis among cirrhotic patients. Conclusions: Combined NLR and CRP with cut of >2.9, and >15 mg/dl respectively could be used as a novel, non-invasive predictor for SBP diagnosis.