Predictive Value of Neutrophil to Lymphocyte Ratio Combined with C-Reactive Protein for Diagnosis of Spontaneous Bacterial Peritonitis among Cirrhotic Patients

Document Type : Original Article

Authors

Abstract

Background: A serious problem for cirrhotic individuals is spontaneous bacterial peritonitis (SBP). Clinical significance of SBP's C-reactive protein (CRP) as well as neutrophil-to-lymphocyte ratio (NLR) have been discovered using varying threshold levels. Objective: The aim of the current work was to assess the validity of diagnostic paracentesis with the use of combined blood NLR and CRP as a non-invasive predictor for early diagnosis of SBP.
Patients and Methods: This case control study included a total of 60 cirrhotic decompensated patients, admitted at Department of Tropical Medicine, Zagazig University Hospitals. Patients were categorized into two groups (30 each) according to neutrophil count in Ascitic fluid; Group I with SBP and Group II free from SBP. Both NLR and CRP were assessed among all subjects.
Results: NLR was statistically significant higher in SBP group. A cut-off value of blood NLR >2.9 on ROC curve had a specificity of 88% as well as sensitivity of 95% for SBP diagnosis in cirrhotic patients. CRP level differed significantly among cirrhotic patients diagnosed with SBP. A cut-off >15 mg/L had a sensitivity and specificity of 85% and 90 % respectively in diagnosing SBP in cirrhotic patients. Combination NLR and CRP had a cut-off >22.6 mg/L, had a sensitivity and specificity of 86%, 91 % respectively in SBP diagnosis among cirrhotic patients.
Conclusions: Combined NLR and CRP with cut of >2.9, and >15 mg/dl respectively could be used as a novel, non-invasive predictor for SBP diagnosis.
 

Keywords

The Egyptian Journal of Hospital Medicine
Volume 91, Issue 1
April 2023
Pages 4380-4386

Files

Share

How to cite

Statistics