Saleh, S., Yousef, G., Khodir, S., Elziat, A., Amer, G. (2023). The Impact of Alpha-lipoic acid on the Monosodium Glutamate Induced Motor Coordination Dysfunction in Rats. The Egyptian Journal of Hospital Medicine, 91(1), 4001-4010. doi: 10.21608/ejhm.2023.294167
Safaa M. Saleh; Gerges S. Yousef; Suzan A. Khodir; Amany F. Elziat; Ghana S. Amer. "The Impact of Alpha-lipoic acid on the Monosodium Glutamate Induced Motor Coordination Dysfunction in Rats". The Egyptian Journal of Hospital Medicine, 91, 1, 2023, 4001-4010. doi: 10.21608/ejhm.2023.294167
Saleh, S., Yousef, G., Khodir, S., Elziat, A., Amer, G. (2023). 'The Impact of Alpha-lipoic acid on the Monosodium Glutamate Induced Motor Coordination Dysfunction in Rats', The Egyptian Journal of Hospital Medicine, 91(1), pp. 4001-4010. doi: 10.21608/ejhm.2023.294167
Saleh, S., Yousef, G., Khodir, S., Elziat, A., Amer, G. The Impact of Alpha-lipoic acid on the Monosodium Glutamate Induced Motor Coordination Dysfunction in Rats. The Egyptian Journal of Hospital Medicine, 2023; 91(1): 4001-4010. doi: 10.21608/ejhm.2023.294167
The Impact of Alpha-lipoic acid on the Monosodium Glutamate Induced Motor Coordination Dysfunction in Rats
Background: Monosodium Glutamate (MSG) is one of the most commonly used flavors that may lend to motor incoordination. Alpha-lipoic acid (ALA) has antioxidant and anti-inflammatory effects with neuro-protective effects.
Objectives: Present work aimed to elucidate possible protective potential of ALA on the motor incoordination induced by MSG and the possible underlying mechanisms. Materials and Methods: Seventy male Wister albino rats were randomized into five groups: 1-Control group (10 rats). 2-MSG group (20 rats): MSG 3 wks and MSG 6 wks ten rats each. 3-ALA pretreated group (10 rats). 4-ALA cotreated group (20 rats): ALA cotreated 3 wks and ALA cotreated 6 wks ten rats each. 5-Alpha-Lipoic acid-post- group. Thereafter, motor coordination assessed using Rotarod and Footprint analysis were assessed in addition to serum Malondialdehyde (MDA), total antioxidant capacity (TAC), Tumor necrosis factor- alpha (TNF- α), cerebellar brain derived neurotrophic factor (BDNF) and Oxidative DNA damage were measured. Also, histo-pathological examination of cerebellar tissue was performed and number of purkinjie cells was assessed. Results: ALA resulted in better improvement for MSG-induced motor incoordination, oxidative impairment and microscopic alterations of cerebellar architecture in cotreated group than that of post-treated group, with insignificant change in pretreated group. Conclusion: ALA exhibit protective effect against motor incoordination, oxidative stress and cerebellar damage induced by MSG toxicity best as cotreatment, less when used as post-treatment but this effect useless as pretreatment.
View on SCiNiTO
Top