The Effectiveness of Radioactive Iodine for Treatment of Well Differentiated Thyroid Carcinoma with Distant Metastases (10 Years Study)

Document Type : Original Article

Authors

Clinical Oncology and Nuclear Medicine, Mansoura University Hospitals, Mansoura, Egypt

Abstract

Background:The most prevalent endocrine malignancy is thyroid carcinoma. It accounts for around 3% of all recently found cancer cases. More than 90% of endocrine neoplasms are accounted for by it. Thyroid cancer accounts for around 1% of all cancer deaths worldwide. Objective: The study's goal was to assess the effect of radioactive iodine alone or in combination with other treatment modalities, on overall survival (OS) and prognostic OS characteristics in metastatic well differentiated thyroid carcinoma (DTC) after total or near-total thyroidectomy.
Patients and Methods: We reviewed all the files of patients diagnosed with cancer thyroid attended to Clinical Oncology and Nuclear Medicine Department, Mansoura University Hospital from January 2012 to the end of December 2021 to get the number of well DTC with distant metastases. 70 patients with DTC with distant metastases were included in this retrospective analysis.
Results: The median OS from well DTC with distant metastases diagnosis was 79.06 months and it was significantly reduced in case of male sex and T4 stage. Among 70 patents diagnosed with DTC with distant metastases, 12 cases lost follow up, 5 patients (8.62%) achieved complete response following RAI treatment, either alone or in combination with radiotherapy. Age below 55 years, poor performance status and staging were predictive for complete response, Conclusion: Radioactive iodine therapy is an effective method in the treatment of DTC with distant metastases since it reduces the number of adverse events while maintaining a high standard of living and improves OS.
 

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The Egyptian Journal of Hospital Medicine
Volume 90, Issue 2
January 2023
Pages 3695-3702

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