Hypervirulent Klebsiella pneumoniae at Benha University Hospitals

Document Type : Original Article

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Abstract

Background: Hypervirulent Klebsiella pneumoniae (hvKP) is a virulent subtype of K. Pneumoniae. It commonly causes a serious community acquired infections, but it can also cause hospital acquired (nosocomial) infections. Emergence of antimicrobial resistance in hvKP ia a cause of concern.
Objective: Phenotypic and molecular characterization and differentiation of classical and hypervirulent klebsiella pneumoniae isolated from Benha University Hospital. Subjects and methods: Klebsiella pneumoniae was isolated bycultivation on Mac-Conkey agar media. Identified phenotypically and subjected to antibiotic sensitivity test. Conventional PCR was performed for detection of RmpA and RmpA2 virulence genes.
Results: Eight strains out of 70 (11.4%) K.Pneumoniae were identified as probable hvKP by detection of RmpA2 that was detected in all hvKP while rmpA was detected in 2 out of 8 hvKP isolates. Both cKP and hvKP isolates exhibited high resistance rates for most of the tested antibiotics.
Conclusion: Particularly in the presence of antibiotic resistance, HvKP pose a new hazard. Both Rmp A and Rmp A2 virulence genes were strongly associated with hvKP.
 

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The Egyptian Journal of Hospital Medicine
Volume 90, Issue 2
January 2023
Pages 3592-3597

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