Changes in Pulmonary Function Tests in Pediatrics with End- Stage Renal Disease in Benha University Hospitals

Afify, Wesam E.; Abd ElMonem, Abd ElHamed; Mohammed, Etemad A.; Orfy, Ahmed Mohammed Ali; Allam, Amira H.; Elbalshy, Mostafa G.

doi:10.21608/ejhm.2023.291964

Changes in Pulmonary Function Tests in Pediatrics with End- Stage Renal Disease in Benha University Hospitals

Document Type : Original Article

Authors

10.21608/ejhm.2023.291964

Abstract

Background: Patients with end-stage renal disease (ESRD) receiving regular hemodialysis (HD) may experience acute or chronic pulmonary problems, which are one of the leading causes of death in this population. Physical deconditioning, muscular atrophy from lack of usage, weakness, exhaustion, lower-limb edema, and back discomfort can all contribute to a decline in the lung's functional capacity, which makes it difficult for these kids to accomplish everyday tasks.
Objective: The aim of the current work was to examine pulmonary function testing in kids with ESRD receiving routine HD.
Patients and Methods: This comparative cross-sectional study included a total of 26 Children with ESRD on regular HD and equal number of age and gender matched controls, attending at Inpatient Clinic, Pediatric Nephrology Department, Pediatric Hospital, Benha University Hospitals.
Results: The present study showed that, mean values of forced expiratory volume in 1 second (FEV1) (%),forced vital capacity (FVC) (%), Peak expiratory flow (PEF) (%), maximal voluntary ventilation (MVV) (%), forced expiratory flow (FEF) (25-75) were statistically lower among hemodialysis group than Control group.However, there was no statistically significant difference in FEV1/FVC (%) between the hemodialysis group and the Control group. In the current study, 57.7% of the ESRD patients evaluated had restrictive spirometric patterns, 7.7% had mixed obstructive and restrictive patterns, and 7.7% had obstructive patterns.
Conclusion: Our results support the notion that pulmonary function tests considerably decline in ESRD patients receiving HD compared to controls, with a strong negative connection between this and the length of dialysis. The majority of ESRD patients first displayed aberrant pulmonary functions, with a restrictive pattern predominating.

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