Abdel Wahab, N., AbdAlkader, Z., Abdel Sameea, A., Ahmed, H. (2023). Study of Possible Effect of Atorvastatin on Memory and Cognition in Normal and High Fat Diet Fed Adult Male Albino Rats. The Egyptian Journal of Hospital Medicine, 90(2), 3476-3483. doi: 10.21608/ejhm.2023.291466
Nada Mohamed Hassan Abdel Wahab; Zaki Youssef AbdAlkader; Ahmed Ahmed Abdel Sameea; Heba Sabry Ahmed. "Study of Possible Effect of Atorvastatin on Memory and Cognition in Normal and High Fat Diet Fed Adult Male Albino Rats". The Egyptian Journal of Hospital Medicine, 90, 2, 2023, 3476-3483. doi: 10.21608/ejhm.2023.291466
Abdel Wahab, N., AbdAlkader, Z., Abdel Sameea, A., Ahmed, H. (2023). 'Study of Possible Effect of Atorvastatin on Memory and Cognition in Normal and High Fat Diet Fed Adult Male Albino Rats', The Egyptian Journal of Hospital Medicine, 90(2), pp. 3476-3483. doi: 10.21608/ejhm.2023.291466
Abdel Wahab, N., AbdAlkader, Z., Abdel Sameea, A., Ahmed, H. Study of Possible Effect of Atorvastatin on Memory and Cognition in Normal and High Fat Diet Fed Adult Male Albino Rats. The Egyptian Journal of Hospital Medicine, 2023; 90(2): 3476-3483. doi: 10.21608/ejhm.2023.291466
Study of Possible Effect of Atorvastatin on Memory and Cognition in Normal and High Fat Diet Fed Adult Male Albino Rats
Background: Atorvastatin reduces blood cholesterol levels, although there is evidence linking statins in general to memory loss. Objective: To evaluation of atorvastatin effects against memory and cognition in normal and hyperlipidemic male albino rats. Materials and methods: 24 male adult albino rats, have been used and in random way divided into four groups with six rats in each group as follows; 1) Control group: normal diet group, 2) HFD group: orally HFD-fed group in a dose of (15 gram/animal/day) for 28 days, 3) Atorvastatin/ordinary diet group: treated with atorvastatin orally (10 mg/kg/day) for 14 days; from 29th day to 42nd day of the study, 4) Atorvastatin/HFD group: treated with atorvastatin orally (10 mg/kg/day) for 14 days; from the 29th day to the 42nd day of the study. Assessment of working memory and spatial learning was performed after the 42nd day of the experiment. Results: Treatments with atorvastatin were significantly ameliorated this lipid dysfunction as it significantly reduced cholesterol, LDL-C and VLDL levels, increased HDL-C levels but did not affect triglycerides. Atorvastatin exhibited beneficial effects against hyperlipidemia induced by HFD treatment. Administration of atorvastatin in atorvastatin/ordinary diet-fed group also induced a statistically significant increase in AchE level in comparison with control group, while administration of atorvastatin attenuated AchE in Atorvastatin/HFD group compared with non-treated HFD group. Conclusion: Administration of atorvastatin in atorvastatin/ordinary diet-fed group also induced an oxidative status as indicated by disturbance of oxidative stress markers (GSH, and CAT), while administration of atorvastatin in Atorvastatin/HFD group improved both oxidative stress markers (GSH, and CAT) as well as inflammatory markers (TNF-α and IL-1β) compared with non-treated HFD group.
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