Evaluation of the Level of Interleukins 13 and 33 in the Serum of ‎Patients with Renal Failure in Kirkuk City

Abdullai, Muthana N.; Fahad, Hayfaa M.; Mushrif, Mohammed H.

doi:10.21608/ejhm.2023.291461

Evaluation of the Level of Interleukins 13 and 33 in the Serum of ‎Patients with Renal Failure in Kirkuk City

Document Type : Original Article

Authors

10.21608/ejhm.2023.291461

Abstract

Background: A poor prognosis and a high death rate are associated with chronic progressive renal ‎loss of parenchymal function.
Objective: This study aimed to ascertain the relationship between interleukin (IL)-13 and ‎IL-33 and kidney failure and their function as inflammatory markers‎.
Patients and methods: Study participants ranged in age from 17 to 75 and were admitted to the Dialysis ‎Unit of Kirkuk General Hospital. They included 45 clinically diagnosed patients (15 patients with Candida albicans infection and 30 without infection), and 45 ‎healthy controls. Immunological tests of IL-33 and IL-13 were done using ELISA‎.
Results: The mean value of IL-13 was significantly higher among the cases group than in ‎the control group (184.08 ± 60.79 vs ‎120.44 ± 22.67‎, P=0.000). Likewise, the mean ‎level of IL-33 was significantly higher among renal failure patients than those in ‎the renal failure-free group‎.
Conclusions: The present study showed increase in IL33 levels in serum of renal failure patients when compared with the control group. Whereas, the IL13 and IL-33 levels in the serum of renal failure patients with Candida albicans infection were higher than in renal failure patients without Candida albicans.

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