Fathy, H., Mohamed, R., Korany, M., Abd-ElAzeem, M. (2023). Relation of Serum Beta 2 Microglobulin Levels to Systemic Lupus Disease Manifestations and Disease Activity. The Egyptian Journal of Hospital Medicine, 90(2), 3209-3214. doi: 10.21608/ejhm.2023.291002
Hossam Marouf Fathy; Rabab Afifi Mohamed; Marwa Gamal Korany; Mervat Ismail Abd-ElAzeem. "Relation of Serum Beta 2 Microglobulin Levels to Systemic Lupus Disease Manifestations and Disease Activity". The Egyptian Journal of Hospital Medicine, 90, 2, 2023, 3209-3214. doi: 10.21608/ejhm.2023.291002
Fathy, H., Mohamed, R., Korany, M., Abd-ElAzeem, M. (2023). 'Relation of Serum Beta 2 Microglobulin Levels to Systemic Lupus Disease Manifestations and Disease Activity', The Egyptian Journal of Hospital Medicine, 90(2), pp. 3209-3214. doi: 10.21608/ejhm.2023.291002
Fathy, H., Mohamed, R., Korany, M., Abd-ElAzeem, M. Relation of Serum Beta 2 Microglobulin Levels to Systemic Lupus Disease Manifestations and Disease Activity. The Egyptian Journal of Hospital Medicine, 2023; 90(2): 3209-3214. doi: 10.21608/ejhm.2023.291002
Relation of Serum Beta 2 Microglobulin Levels to Systemic Lupus Disease Manifestations and Disease Activity
Background:The autoimmune disease systemic lupus erythematosus (SLE) causes inflammation. Activity evaluation could be conducted using a number of different methods. Biomarkers like β2 is a biomarker, which is found on all nucleated somatic cells and its use as a prognostic is under investigation. Objective: The study aimed to assess the association between serum levels of β2 microglobulin (B2M) and disease activity. Patients and Methods: The study included fifty lupus patients and fifty healthy people served as controls. The levels of C-reactive protein (CRP), complement 3, and complement 4, as well as the erythrocyte sedimentation rate (ESR), anti-nuclear antibody (ANA), and anti-double-stranded DNA antibody (dsDNA), were measured. The serum Beta 2-microglobulin (B2M) was measured using an enzyme-linked immunosorbent assay. Results: The serum B2-microglobulin levels were significantly higher in SLE patients (mean values 27.42± 5.5) compared with the controls (6.80± 1.61) (P value =0.001). In contrast to inactive individuals, active patients had a greater mean serum B2-microglobulin concentration. Conclusion: A good correlation between B2M and SLE disease activity may explain the role of this marker in the inflammatory process.
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