Salih, Z., Al-Khedairy, E. (2023). Amino Acid as Co-Crystal Coformer for Ebastine Solubility Enhancement. The Egyptian Journal of Hospital Medicine, 90(2), 2900-2908. doi: 10.21608/ejhm.2023.287835
Zainab M. Salih; Eman B. H. Al-Khedairy. "Amino Acid as Co-Crystal Coformer for Ebastine Solubility Enhancement". The Egyptian Journal of Hospital Medicine, 90, 2, 2023, 2900-2908. doi: 10.21608/ejhm.2023.287835
Salih, Z., Al-Khedairy, E. (2023). 'Amino Acid as Co-Crystal Coformer for Ebastine Solubility Enhancement', The Egyptian Journal of Hospital Medicine, 90(2), pp. 2900-2908. doi: 10.21608/ejhm.2023.287835
Salih, Z., Al-Khedairy, E. Amino Acid as Co-Crystal Coformer for Ebastine Solubility Enhancement. The Egyptian Journal of Hospital Medicine, 2023; 90(2): 2900-2908. doi: 10.21608/ejhm.2023.287835
Amino Acid as Co-Crystal Coformer for Ebastine Solubility Enhancement
Background: Ebastine (EB) is a selective, nonsedating H1 antihistamine belonging to Class II(BCS); its insufficient water solubility limits its oral bioavailability. Cocrystal is one of the most modern techniques used to increase the solubility and dissolving rate of a medicine, among other physicochemical properties. Aim: The primary purpose of this study was to construct and assess EB cocrystal as an experiment to improve its solubility. Methods: Various processes, such as solvent evaporation and liquid asset grinding with varying molar ratios of amino acid as a co-former, have been used to produce cocrystals. The produced formulations were evaluated by yield %, drug content, saturation solubility, in vitro dissolution tests, Powder X-ray Diffraction (PXRD), and scanning electron microscopy. Results: Increased solubility by 364 times in distilled water with an improved dissolving profile. Conclusion: Due to its ability to enhance physicochemical and mechanical qualities, co-crystallization is a promising method for solid formation. Using unique hydrogen bond synthon motifs, co-crystals have been successfully produced from several medications and co-former