Brief Overview about Correlation between CD8 and Multiple Sclerosis: Review Article

Abd El Ghaffar, Adel Saeed; Mohamed, Hanan Salah; Zidan, Amal Ahmed; Alhadi, Waseem Yousuf; Emad, Engy M.

doi:10.21608/ejhm.2023.286404

Brief Overview about Correlation between CD8 and Multiple Sclerosis: Review Article

Document Type : Original Article

Authors

10.21608/ejhm.2023.286404

Abstract

Background: There is now conclusive evidence that multiple sclerosis (MS) belongs to the group of primary neurodegenerative illnesses. Myelin is the protective layer around nerve fibres in the brain and spinal cord, and it is the target of an autoimmune attack in multiple sclerosis, a debilitating neurological illness. Immune protection against intracellular pathogens like viruses and bacteria, as well as tumour surveillance, rely heavily on CD8+ T cells. There are three main mechanisms that CD8+ T lymphocytes use to eliminate contaminated or cancerous cells after they have become activated by recognizing their antigen.
Objective: To have overview about Correlation between CD8 and multiple sclerosis.
Methods: We looked for data on CD8, T cell and multiple sclerosis in medical journals and databases like PubMed, Google Scholar, and Science Direct. However, only the most recent or extensive study was taken into account between January 2000 and May 2021. References from related works were also evaluated by the writers. There are not enough resources to translate documents into languages other than English, hence those documents have been ignored. It was generally agreed that documents such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations did not qualify as legitimate scientific study.
Conclusion: Autoreactive CD8+ cytotoxic T cells significance in the pathogenesis of multiple sclerosis is becoming increasingly apparent. It is of great interest to learn whether or not these CD8+ Tregs play a function in regulating the progression of multiple sclerosis.

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