Al-maragy, A., Rakha, M., abou-Zeed, A., Ahmed, M. (2019). Measurement of Helicobacter Pylori in Patients with Bronchial Asthma. The Egyptian Journal of Hospital Medicine, 74(8), 1725-1731. doi: 10.21608/ejhm.2019.28578
Abaas Saeed Al-maragy; Mohammed Abdallah Rakha; Ahmed Abdel-Hameed abou-Zeed; Mohanad Mohammed Ahmed. "Measurement of Helicobacter Pylori in Patients with Bronchial Asthma". The Egyptian Journal of Hospital Medicine, 74, 8, 2019, 1725-1731. doi: 10.21608/ejhm.2019.28578
Al-maragy, A., Rakha, M., abou-Zeed, A., Ahmed, M. (2019). 'Measurement of Helicobacter Pylori in Patients with Bronchial Asthma', The Egyptian Journal of Hospital Medicine, 74(8), pp. 1725-1731. doi: 10.21608/ejhm.2019.28578
Al-maragy, A., Rakha, M., abou-Zeed, A., Ahmed, M. Measurement of Helicobacter Pylori in Patients with Bronchial Asthma. The Egyptian Journal of Hospital Medicine, 2019; 74(8): 1725-1731. doi: 10.21608/ejhm.2019.28578
Measurement of Helicobacter Pylori in Patients with Bronchial Asthma
1Department of Chest Diseases, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
2Department of Clinical pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Abstract
Background: Current evidence indicates an inverse association between Helicobacter pylori and asthma and allergy. H. pylori is a Gram-negative bacterium which represents the major cause of peptic ulcer and gastric cancer, and preferentially elicits a T helper (Th)-1 response. Many H. pylori factors, such as the neutrophil-activating factor of H. pylori (HP-NAP), are able to drive Th-1 polarization and to display a powerful inhibition of allergic Th-2 response. Special attention has been drawn to HP-NAP as a potential novel strategy for the prevention and treatment of asthma and atopy. Aim of the Work: This study was aimed to measure helicobacter pylori in patient with bronchial asthma. Subjects and Methods: This study included a total of 50 patients with bronchial asthma and 20 age-matched control individuals attending at AL-Hussein, Al-Azhar University Hospitals in the period between April 2018 and December 2018. All patients underwent full history taking, complete clinical examination, plain chest X-ray, routine lab investigations, spirometry before and after bronchodilators and H. pylori antigen in stool by ELISA. Results: The results of this study revealed that there is a relation between bronchial asthma and helicobacter pylori. Conclusion: There were improvement in pulmonary function tests in asthmatic patients with H. pylori positive more than asthmatic patients with H. pylori negative.
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