Histopathological Study of the Chronic Toxic Effects of Dapoxetine Administration on Testes of Male Albino Rats

Document Type : Original Article

Authors

Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Abstract

Background: Dapoxetine is a short acting oral SSRI, purely created for the on-demand treatment of premature ejaculation. The present study was carried out to see the histopathological effects of Dapoxetine on the testis of adult albino rats. Materials and methods: Dapoxetine was administered orally by gavage to rats for consecutive 70 days, Eighty apparently healthy male albino rats weighing 125–150 g were used throughout the experiments .The rats were divided randomly into four groups (n=6). Each group 20 rats: Group (1) Control group, Group (2) receiving 1 mg of dapoxetine /70 days, Group (3) receiving 5 mg of dapoxetine /70 days and Group (4) receiving 10 mg of dapoxetine /70 days. Histological slides were prepared and stained with H and E stain. On examination, distortion of seminiferous tubules, decreased thickness of germinal epithelium, decreased diameter of seminiferous tubules and decreased counts of germinal cell lineage were found in treated groups.

Keywords

The Egyptian Journal of Hospital Medicine
Volume 74, Issue 8
January 2019
Pages 1698-1701

Files

Share

How to cite

Statistics