Mikhael, N., Elfallah, A., Ahmed, A., khalil, K. (2023). Vitamin B12 and Brain-Derived Neurotrophic Factor in Diabetic Patients with Chronic Generalized Pruritus. The Egyptian Journal of Hospital Medicine, 90(1), 1903-1909. doi: 10.21608/ejhm.2023.284760
Nancy Wadie Mikhael; Asmaa A. Elfallah; Alzahraa Mosa Ahmed; Karem Taha khalil. "Vitamin B12 and Brain-Derived Neurotrophic Factor in Diabetic Patients with Chronic Generalized Pruritus". The Egyptian Journal of Hospital Medicine, 90, 1, 2023, 1903-1909. doi: 10.21608/ejhm.2023.284760
Mikhael, N., Elfallah, A., Ahmed, A., khalil, K. (2023). 'Vitamin B12 and Brain-Derived Neurotrophic Factor in Diabetic Patients with Chronic Generalized Pruritus', The Egyptian Journal of Hospital Medicine, 90(1), pp. 1903-1909. doi: 10.21608/ejhm.2023.284760
Mikhael, N., Elfallah, A., Ahmed, A., khalil, K. Vitamin B12 and Brain-Derived Neurotrophic Factor in Diabetic Patients with Chronic Generalized Pruritus. The Egyptian Journal of Hospital Medicine, 2023; 90(1): 1903-1909. doi: 10.21608/ejhm.2023.284760
Vitamin B12 and Brain-Derived Neurotrophic Factor in Diabetic Patients with Chronic Generalized Pruritus
dermatology andrology department, faculty of medicine benha university,egypt
Abstract
Background: A common and bothersome condition with a complicated pathophysiology, including neuropathy, is diabetes-related pruritus. The growth factor known as "brain-derived neurotrophic factor" (BDNF) affects how nerve cells survive, differentiate, and are maintained. Objectives: To measure the serum levels of BDNF and vitamin B12 (vitB12) in diabetic patients with generalized Pruritus. Patients and Methods: One hundred fifty participants were included in this case-control research. They were split into three equal groups: diabetes patients with chronic generalized pruritus (n=50), diabetic patients with no pruritus (n=50), and normal age-sex matched control subjects (n=50). Complete clinical information, including the duration of diabetes, the duration of pruritus, and a history of drugs, was gathered. Using the 12-Item Pruritus Severity Scale (12-PSS), the severity of the pruritus was evaluated. A thorough general and dermatological evaluation was performed. Lab tests included FBS, PPBS, and HbAIC. Additionally, ELISA was used to measure the serum levels of BDNF and vitB12. Results: Serum vitB12 and BDNF levels were significantly different among the study groups (P=0.000, P=0.000, respectively) with higher levels in diabetics compared to controls. Diabetics with pruritus exhibited higher vitB12, BDNF levels than diabetic non-pruritic group (P1=0.005, P1=0.000, respectively). Both vitB12 and BDNF showed significant positive correlation with 12-PSS (r=0.499, P=0.000; r=0.513, P=0.000, respectively). BDNF was positively correlated with vitB12 (r=0.518, P=0.000). There was a significant positive correlation between BDNF and the duration of diabetes and FBS, PPBS, HbA1C (P=0.000). Conclusion: Increased serum levels vitB12 and BDNF levels might explain the cause of chronic generalized pruritus in diabetic patients.
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