Diagnostic Value of Interleukin 1 Receptor Antagonist (IL-1RA) in Children with Refractory Epilepsy

Document Type : Original Article

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Abstract

Background: Clinical studies have shown that prolonged seizures result in increased cytokine production in the central nervous system. Aim of work: To focus on diagnostic value of interleukin-1 receptor antagonists in refractory epilepsy.
Patients and methods: This case-control investigation was done in Pediatric Neurology Unit and Pediatric Neurology Clinics, Faculty of Medicine, Zagazig University. Children were classified into: patient group: 59 children with refractory epilepsy aged between 1 year and 16 years old and control group: 59 healthy children who are age and sex corresponded to the patient population. Serum level of IL-1Ra was assessed. Results: There is significant higher value of plasma of interleukin1 receptor antagonist in studied refractory epilepsy group compared to the healthy control group.
Conclusion: Interleukin-1 receptor antagonist can differentiate the control group and the seizure group.
 

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The Egyptian Journal of Hospital Medicine
Volume 90, Issue 1
January 2023
Pages 1611-1616

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