Study the Level of the Pregnancy Associated Plasma Protein-A (PAPP-A) Isolated from Mature Retrieved Oocyte during ICSI Protocol in Iraqi Infertile women

Yousif, Zainab Omar; Salih, Lina A.

doi:10.21608/ejhm.2023.282370

Study the Level of the Pregnancy Associated Plasma Protein-A (PAPP-A) Isolated from Mature Retrieved Oocyte during ICSI Protocol in Iraqi Infertile women

Document Type : Original Article

Authors

10.21608/ejhm.2023.282370

Abstract

Background: The total number of oocytes, oocyte maturation, and oocyte fertilization all significantly affect how successful in vitro fertilization (IVF) is. Additionally, it has been demonstrated that several chemicals in follicular fluid, including cytokines and growth factors, have a major impact on follicular maturation, ovulation, and follicular atresia. One of these molecules, Pregnancy Associated Plasma Protein-A (PAPP-A), a part of the Insulin like Growth Factor (IGF) pathway, has been demonstrated to be generated by granulosa cells and present in follicular fluid. Objective: The aim of this study is to measure the level of Pregnancy Associated Plasma Protein-A (PAPP-A) in Follicular Fluid (FF) of infertile women undergoing ICSI, and to looking into the connections of PAPP-A with some reproductive hormones level.
Patients and methods: The study included infertile women from Al-Wazyria Hospital, Infertility and IVF Center, Baghdad (Iraq), from December 2021 to April 2022. This study was conducted on 45 infertile women who are set to start their ICSI cycle.
Results: FF PAPP-A was not significant with hormones level (FSH, LH, E2 and AMH) except PRO hormone was significant.
Conclusion: Outcomes show that no relation between studied reproductive hormones and FF PAPP-A level except PRO levels; it was the main cause from the egg to mature and release from the ovary.

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