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Helal, E., Al-Shamrani, A., Abdelaziz, M., El-Gamal, M. (2019). Comparison between The Effect of Sucralose and Sodium Saccharin on Some Physiological Parameters in Male Albino Rats. The Egyptian Journal of Hospital Medicine, 74(7), 1552-1558. doi: 10.21608/ejhm.2019.28025
Eman G.E. Helal; Abdullah Al-Shamrani; Mohamed A. Abdelaziz; Mariam S. El-Gamal. "Comparison between The Effect of Sucralose and Sodium Saccharin on Some Physiological Parameters in Male Albino Rats". The Egyptian Journal of Hospital Medicine, 74, 7, 2019, 1552-1558. doi: 10.21608/ejhm.2019.28025
Helal, E., Al-Shamrani, A., Abdelaziz, M., El-Gamal, M. (2019). 'Comparison between The Effect of Sucralose and Sodium Saccharin on Some Physiological Parameters in Male Albino Rats', The Egyptian Journal of Hospital Medicine, 74(7), pp. 1552-1558. doi: 10.21608/ejhm.2019.28025
Helal, E., Al-Shamrani, A., Abdelaziz, M., El-Gamal, M. Comparison between The Effect of Sucralose and Sodium Saccharin on Some Physiological Parameters in Male Albino Rats. The Egyptian Journal of Hospital Medicine, 2019; 74(7): 1552-1558. doi: 10.21608/ejhm.2019.28025

Comparison between The Effect of Sucralose and Sodium Saccharin on Some Physiological Parameters in Male Albino Rats

Article 12, Volume 74, Issue 7, January 2019, Page 1552-1558  XML PDF (675.33 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.28025
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Authors
Eman G.E. Helalorcid 1; Abdullah Al-Shamrani2; Mohamed A. Abdelaziz3; Mariam S. El-Gamal1
1Department of Zoology, Faculty of Science (Girls), Al-Azhar University
22Pediatric Pulmonology and Sleep Medicine, Prince Sultan Medical Military City, King Saud bin Abdulaziz University and Health Science
3Medical Physiology, Faculty of Medicine, Al-Azhar University
Abstract
Background: Non-nutritive sweeteners (NNSs) are becoming popular as sugar substitutes for diabetic patients or to decrease body weight. Aim of the work: This study was aimed to determine the effects of sucralose and sodium saccharin on some physiological parameters in male albino rats. Materials and methods: We used thirty male albino rats weighing from 100 to120 gm. The period of the experiment was 30 days. The animals were divided into three groups; Group 1: control, Group 2: rats received sucralose and group 3: rats received sodium saccharin. The following parameters were processed: serum glucose, ASAT, ALAT, serum creatinine, serum urea, protein and lipid profiles and hormonal levels (insulin, testosterone, serum T3 and T4). Results: There was an increase in ASAT and ALAT activities, serum creatinine and serum urea levels in group 2 and group 3, lipid profile in the group received sucralose (TC and HDL) and T3&T4 in the group received saccharin as compared to the control group. Meanwhile, a drop in serum glucose, insulin, total protein, albumin, albumin/globulin ratio and triglycerides in group 2 and group 3, lipid profile in the group received saccharin (TC and HDL) and T3&T4 in the group received sucralose was observed when compared to the control group. Conclusion: it could be concluded that sucralose and sodium saccharin must be carefully used because they have very dangerous effects-especially sodium saccharin- and we have to replace them with natural sugar.
Keywords
sucralose; sodium saccharin; ASAT; ALAT; T3; T4; testosterone; Insulin
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