Levels of Serum Procollagen Type‐1 Amino Terminal Propeptide and C‐terminal Cross‐linked Telopeptide of Type‐1 Collagen in Children and

Afify, Mohamed A. M.; Hassanin, Alaa; Eladawy, Rasha

doi:10.21608/ejhm.2023.280204

Levels of Serum Procollagen Type‐1 Amino Terminal Propeptide and C‐terminal Cross‐linked Telopeptide of Type‐1 Collagen in Children and

Document Type : Original Article

Authors

10.21608/ejhm.2023.280204

Abstract

Background: In patients with type 1 diabetes mellitus (T1DM), accelerated bones turnover and bone loss are caused by increased inflammation. The serum levels of the bones turnover markers (BTM), serum procollagen type 1 N-terminal propeptide (P1NP) and serum C-terminal telopeptide of type I collagen (CTX), can help identify increasing bones fragility in T1DM earlier on.Objective: The aim of the study is to measure the levels of BTM in children with T1DM, specifically serum P1NP and serum CTX, and to look into the relationships between BTM and indicators of glycemic control and diabetics micro-vascular problems.
Patients and methods: A total of 40 pediatric and adolescent T1DM children were compared with a control group of healthy control, age- and sex-matched participants. HbA1c, fasting lipids profiles, microalbumin in urine, fasting serum P1NP, and serum CTX concentrations were measured in the laboratory.
Results: P1NP and CTX concentrations in the sick group were statistically significantly higher than those in the control group (p < 0.001), according to the findings of our research. LDL-C and TDD of insulin, which rose in the uncontrolled sample, were determined to differ significantly between participants with HbA1c ≤7% and participants with HbA1c ≥7% (p < 0.001 and p=0.008, respectively), although there was no differences in the levels of serum P1NP and CTX between the two samples. Conclusion: In younger T1DM children, serum concentrations of P1NP and CTX may offer predictive information on bones health. To demonstrate that oxidative stress causes major changes in the activities of bone production and resorption, more research should be conducted.

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