Serum Vitamin D Deficiency in Idiopathic Preterm Labor: Case Control Study

Zeinhom, Ahmed M.; Kamal, Ahmed F.; Mostafa, Mohamed H.; Abdel Wahed, Mai Magdy; Farid, Laila A.

doi:10.21608/ejhm.2023.279959

Serum Vitamin D Deficiency in Idiopathic Preterm Labor: Case Control Study

Document Type : Original Article

Authors

10.21608/ejhm.2023.279959

Abstract

Background: Preterm labor (PTL) is the most common cause of neonatal death worldwide. In Egypt, the average rate of preterm labor is estimated to be 14.7%. Objective: This study aimed to evaluate the relation between maternal vitamin D deficiency and idiopathic preterm birth.
Patients and Methods: This case-control study was conducted on 160 pregnant women; 80 women with PTL as cases and another 80 women with term birth as controls, who were admitted to the Obstetrics and Gynecology Department in Ain Shams University Maternity Hospital.
Results: Using ROC curve, serum 25(OH) D level ≤ 32 ng/ml was significantly associated with PTL (p = 0.001), with moderate sensitivity of 80% and low specificity of 47.5%.
Conclusion: Preterm delivery was significantly associated with vitamin D ≤ 32.0 ng/ml. Although serum 25(OH) D deficiency is a significant risk factor, but it cannot be considered a diagnostic tool in predicting PTL.

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