Serum Sphingosine 1-Phosphate as a Biomarker for Post-Stroke Cognitive Impairment

Shokry, Aya; Abdel Azim, Ghada; Abozaid, Sarah; Osman, Marwa

doi:10.21608/ejhm.2023.279622

Serum Sphingosine 1-Phosphate as a Biomarker for Post-Stroke Cognitive Impairment

Authors

¹ Department of Neurology, Stroke Unit, Shebin El Koum Teaching Hospital, General Organization for Teaching Hospitals and Institutes, Egypt

² Departments of Neurology, Faculty of Medicine for Girls, Al-Azhar University, Egypt

³ Departments of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Egypt

10.21608/ejhm.2023.279622

Abstract

Background: Stroke is a main cause of disability. Impaired cognition is an important aspect for stroke survivors. The discovery of laboratory biomarkers for post stroke cognitive impairment (PSCI) may help identification of those who are at risk of cognitive impairment and application of suitable therapeutic regimens.
Objective: This study aimed to measure S1P serum levels in a group of patients with severe ischemic stroke at admission and to determine if they are associated with post stroke cognitive state.
Patients and Methods: The study has been applied on sixty patients who had acute ischemic stroke in addition to 40 apparently healthy. The mean of age and gender in subjects and controls were matched. Serum sphingosine -1 phosphate (S1P) levels were analyzed by ELISA technique for all patients within 72 hours of admission and for healthy controls. The severity of the stroke has been evaluated based on the scale of the National Institute of Health Stroke (NIHSS). Patients also underwent cognitive assessment using Montreal Cognitive Assessment (MoCA) at admission and after 3 months.
Results: The level of serum S1P was apparently reduced in acute stroke patients by comparing with the healthy controls (p < 0.001). Furthermore, the decreased levels of the S1P serum were obviously with more disease severity as measured by high NIHSS score at admission and with more post stroke cognitive impairment as assessed by MoCA scale three months later after stroke onset.
Conclusions: The study came up with key findings that reported a clear step-down in the levels of serum S1P in the patients with acute stroke as compared to the healthy control and the same obvious reduction in S1P levels in cognitive impairment patients as compared to those with non-cognitive impairment.

Keywords