Safety and Efficacy of Di-Peptidyl Peptidase-4 Inhibitors in The Management of Inpatient Elderly with Type 2 Diabetes

Authors

Department of Internal Medicine, Faculty of Medicine, Mansoura University, Egypt

Abstract

Background: Hyperglycaemia in hospitalized elderlies with Type 2 Diabetes (T2D) is frequently seen and increases rates of hospital stay, morbidity and mortality. Basal Bolus Regimen (BBR) is the corner stone in management of hyperglycaemia among non-critically ill hospitalized patients. However, it is complex regimen and associated with increased episodes of hypoglycaemia.
Objective: This study was conducted to explore the efficacy and safety of Di-Peptidyl Peptidase -4 inhibitors (DPP-4i) with or without basal insulin for management of T2D among inpatient hospitalized elderly.
Patients and methods: We included 90 patients with T2D, both males and females, aged 60 years or more. Participants were divided into 3 subgroups; Group 1 on BBR using glargine U100 and regular insulin, Group 2 on basal oral regimen using glargine U100 and vildagliptin, and Group 3 on vildagliptin only.
Results: Of all participants, 68 patients were females, and the mean age of the patients was 68.98 (SD 6.7) years. Mean pre-hospital glycated haemoglobin was 8.09 (SD 1.04) gm%. Documented and severe hypoglycaemia and hospital stay were significantly lower among groups 2 and 3. No serious adverse events reported among all participants.
Conclusion: Using DPP-4i with or without basal insulin is safe, effective, less complex regimen associated with lower episodes of documented and severe hypoglycaemia and hospital stay among elderly patients with T2D.

Keywords

The Egyptian Journal of Hospital Medicine
Volume 90, Issue 1
January 2023
Pages 364-371

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