Mousa, Y., H, A., Ibrahim, D., Ahmed, M. (2022). Immunohistochemical Expression of Epithelial and Stromal Annexin A2 (ANXA2) in Colorectal Adenocarcinoma. The Egyptian Journal of Hospital Medicine, 89(2), 7894-7901. doi: 10.21608/ejhm.2022.277383
Yasmen Mohamed Mousa; Abdelbary E. H; Doaa Abdelaziz Ibrahim; Mona Mostafa Ahmed. "Immunohistochemical Expression of Epithelial and Stromal Annexin A2 (ANXA2) in Colorectal Adenocarcinoma". The Egyptian Journal of Hospital Medicine, 89, 2, 2022, 7894-7901. doi: 10.21608/ejhm.2022.277383
Mousa, Y., H, A., Ibrahim, D., Ahmed, M. (2022). 'Immunohistochemical Expression of Epithelial and Stromal Annexin A2 (ANXA2) in Colorectal Adenocarcinoma', The Egyptian Journal of Hospital Medicine, 89(2), pp. 7894-7901. doi: 10.21608/ejhm.2022.277383
Mousa, Y., H, A., Ibrahim, D., Ahmed, M. Immunohistochemical Expression of Epithelial and Stromal Annexin A2 (ANXA2) in Colorectal Adenocarcinoma. The Egyptian Journal of Hospital Medicine, 2022; 89(2): 7894-7901. doi: 10.21608/ejhm.2022.277383
Immunohistochemical Expression of Epithelial and Stromal Annexin A2 (ANXA2) in Colorectal Adenocarcinoma
Background: Colorectal cancer (CRC), the third leading cause of cancer death worldwide, shows rising incidence in developing countries. A combination of environmental and genetic/epigenetic factors contribute to CRC development. Adenocarcinoma not otherwise specified (NOS) is the most common histopathologic subtype. Annexin A2 (ANXA2) is a calcium-regulated phospholipid-binding protein. Objective: Evaluation of the ANXA2 immunohistochemical (IHC) expression in colorectal adenocarcinoma compared to normal mucosaand adenoma and investigating its association with clinicopathological parameters in CRC and adenoma cases. Materials and Methods: This retrospective study included 108 formalin-fixed, paraffin-embedded tissue blocks divided into three groups: adenocarcinoma, normal mucosa, and adenoma. Immunohistochemical staining by ANXA2 antibody was done, followed by semiquantitative evaluation of staining and correlation with clinicopathological data. Results: High ANXA2 expression was significantly increased in CRC compared to normal mucosa and adenoma. Correlation of epithelial and stromal ANXA2 expression with clinicopathological parameters showed a significant association with aggressive cancer phenotypes including higher grade (P =0.003 and<0.001), large size (P = 0.006 and<0.001), deeper depth of invasion (P = 0.003 but 0.084 in stroma), advanced stage (P <0.001 for both), lymph node metastasis (P= 0.001 and <0.001), low lymphocytic infiltration (P <0.001 for both) and high tumor budding grade (P = 0.005 and <0.001). Conclusion: The association of Annexin A2 with aggressive tumor characteristics points to its potential involvement in tumor development, invasion, and metastasis.
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